[HTML][HTML] ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation
Novel approaches are needed to boost the efficacy of immune checkpoint blockade (ICB)
therapy. Ataxia telangiectasia mutated (ATM) protein plays a central role in sensing DNA …
therapy. Ataxia telangiectasia mutated (ATM) protein plays a central role in sensing DNA …
[HTML][HTML] Inhibition of ATR downregulates PD-L1 and sensitizes tumor cells to T cell-mediated killing
The ataxia telangiectasia and Rad3-related (ATR) kinase plays a crucial role in maintaining
genome stability in response to DNA damage. Once activated, ATR acts via its downstream …
genome stability in response to DNA damage. Once activated, ATR acts via its downstream …
ATM in DNA repair in cancer
MH Jin, DY Oh - Pharmacology & therapeutics, 2019 - Elsevier
Alterations in DNA damage response (DDR) pathways are hallmarks of cancer. Incorrect
repair of DNA lesions often leads to genomic instability. Ataxia telangiectasia mutated …
repair of DNA lesions often leads to genomic instability. Ataxia telangiectasia mutated …
Inhibition of ATM increases interferon signaling and sensitizes pancreatic cancer to immune checkpoint blockade therapy
Combinatorial strategies are needed to overcome the resistance of pancreatic cancer to
immune checkpoint blockade (ICB). DNA damage activates the innate immune response …
immune checkpoint blockade (ICB). DNA damage activates the innate immune response …
ATM mutations in cancer: therapeutic implications
Activation of checkpoint arrest and homologous DNA repair are necessary for maintenance
of genomic integrity during DNA replication. Germ-line mutations of the ataxia telangiectasia …
of genomic integrity during DNA replication. Germ-line mutations of the ataxia telangiectasia …
A new class of selective ATM inhibitors as combination partners of DNA double-strand break inducing cancer therapies
Radiotherapy and chemical DNA-damaging agents are among the most widely used
classes of cancer therapeutics today. Double-strand breaks (DSB) induced by many of these …
classes of cancer therapeutics today. Double-strand breaks (DSB) induced by many of these …
Activation of ataxia telangiectasia-mutated DNA damage checkpoint signal transduction elicited by herpes simplex virus infection
N Shirata, A Kudoh, T Daikoku, Y Tatsumi… - Journal of Biological …, 2005 - ASBMB
Eukaryotic cells are equipped with machinery to monitor and repair damaged DNA. Herpes
simplex virus (HSV) DNA replication occurs at discrete sites in nuclei, the replication …
simplex virus (HSV) DNA replication occurs at discrete sites in nuclei, the replication …
Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors
ARID1A, a component of the chromatin-remodeling complex SWI/SNF, is one of the most
frequently mutated genes in human cancer. We sought to develop rational combination …
frequently mutated genes in human cancer. We sought to develop rational combination …
ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion
Ataxia-telangiectasia mutated (ATM) protein kinase regulates the DNA damage response
(DDR) and is associated with cancer suppression. Here we report a cancer-promoting role …
(DDR) and is associated with cancer suppression. Here we report a cancer-promoting role …
ATM: main features, signaling pathways, and its diverse roles in DNA damage response, tumor suppression, and cancer development
LM Phan, AH Rezaeian - Genes, 2021 - mdpi.com
ATM is among of the most critical initiators and coordinators of the DNA-damage response.
ATM canonical and non-canonical signaling pathways involve hundreds of downstream …
ATM canonical and non-canonical signaling pathways involve hundreds of downstream …