ABSTRACT A key problem in evolutionary developmental biology is identifying the sources
of instructive information that determine species-specific anatomical pattern. Understanding …

Embryonic development and regeneration accomplish a remarkable feat: individual cells
work together to create or repair complex anatomical structures. What is the source of the …

Establishment of shape during embryonic development, and the maintenance of shape
against injury or tumorigenesis, requires constant coordination of cell behaviors toward the …

During embryogenesis, tissues and organs are progressively shaped into their functional
morphologies. While the information about tissue and organ shape is encoded genetically …

The development of an organism from an undifferentiated single cell into a spatially complex
structure requires spatial patterning of cell fates across tissues. Positional information …

Research in developmental biology has been recently enriched by a multitude of in vitro
models recapitulating key milestones of mammalian embryogenesis. These models obviate …

Developmental biologists study changes in shape and form of embryonic tissues, the
differentiation of their constituent cell types, the patterned arrangement of the resulting cells …

Multicellular organisms develop complex shapes from much simpler, single-celled zygotes
through a process commonly called morphogenesis. Morphogenesis involves an interplay …

Morphogenetic events during development shape the body plan and establish structural
foundations for tissue forms and functions. Acquiring spatiotemporal information of …

The role of 'generic'physical mechanisms in morphogenesis and pattern formation of tissues
is considered. Generic mechanisms are defined as those physical processes that are …