The tremendous advances in transgene animal technology, especially in the area of
Alzheimer's disease, have not resulted in a significantly better success rate for drugs …

Animal and Translational Models for CNS Drug Discovery combines the experience of
academic, clinical and pharmaceutical neuroscientists in a unique collaborative approach to …

Highlights•Health research depends heavily on animal models, which are frequently
unvalidated.•Disease modelling and drug discovery too often result in translational failure.•A …

Despite great advances in basic neuroscience knowledge, the improved understanding of
brain functioning has not yet led to the introduction of truly novel pharmacological …

The world health organisation has declared neurological disorders as one of the greatest
public health risks in the world today. Yet, despite this growing concern, the mechanisms …

With increasing feasibility of predicting conversion of mild cognitive impairment to dementia
based on biomarker profiling, the urgent need for efficacious disease‐modifying compounds …

Highlights•Innovative 21st-century roadmaps need to be devised for biomedical
research.•Advanced human biology-based models and tools hold the key to …

There is intense interest in the development and application of animal models of CNS
disorders to explore pathology and molecular mechanisms, identify potential biomarkers …

Introduction: The exponential growth in the world's aged population has increased pressure
on drug discovery efforts to identify innovative therapies for Alzheimer's disease (AD). The …

Model organisms of human diseases are invaluable tools for unraveling pathogenic
mechanisms, identifying potential targets for drug development, and evaluating the …