[HTML][HTML] Roles of astrocytic connexin-43, hemichannels, and gap junctions in oxygen-glucose deprivation/reperfusion injury induced neuroinflammation and the …
X Yin, L Feng, D Ma, P Yin, X Wang, S Hou… - Journal of …, 2018 - Springer
Background Glia-mediated neuroinflammation is related to brain injury exacerbation after
cerebral ischemia/reperfusion (I/R) injury. Astrocytic hemichannels or gap junctions, which …
cerebral ischemia/reperfusion (I/R) injury. Astrocytic hemichannels or gap junctions, which …
[HTML][HTML] Astrocytic gap junction inhibition by carbenoxolone enhances the protective effects of ischemic preconditioning following cerebral ischemia
D Ma, L Feng, Y Cheng, M Xin, J You, X Yin… - Journal of …, 2018 - Springer
Background Stroke is the second leading cause of death worldwide and the most common
cause of adult-acquired disability in many nations. Thus, attenuating the damage after …
cause of adult-acquired disability in many nations. Thus, attenuating the damage after …
[HTML][HTML] Inhibition of connexin 43 hemichannels alleviates cerebral ischemia/reperfusion injury via the TLR4 signaling pathway
Y Chen, L Wang, L Zhang, B Chen, L Yang… - Frontiers in Cellular …, 2018 - frontiersin.org
Connexin 43 (Cx43) widely exists in all components of the neurovascular unit (NVU) and is
a constituent of gap junctions and hemichannels. In physiological states, gap junctions are …
a constituent of gap junctions and hemichannels. In physiological states, gap junctions are …
[HTML][HTML] Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling
H Yu, X Cao, W Li, P Liu, Y Zhao, L Song… - Journal of …, 2020 - Springer
Background In the central nervous system (CNS), connexin 43 (Cx43) is mainly expressed
in astrocytes and regulates astrocytic network homeostasis. Similar to Cx43 overexpression …
in astrocytes and regulates astrocytic network homeostasis. Similar to Cx43 overexpression …
Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective
N Froger, JA Orellana, CF Calvo, E Amigou… - Molecular and Cellular …, 2010 - Elsevier
Astrocytes express high levels of connexin43, a protein that forms two types of channels:
gap junction channels for direct intercellular communication, and hemichannels for …
gap junction channels for direct intercellular communication, and hemichannels for …
[HTML][HTML] Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice
R Dong, Y Han, L Jiang, S Liu, F Zhang, L Peng… - Journal of …, 2022 - Springer
Background Postoperative cognitive dysfunction (POCD) is a common complication
following anesthesia and surgery. General anesthetic isoflurane has potential neurotoxicity …
following anesthesia and surgery. General anesthetic isoflurane has potential neurotoxicity …
[HTML][HTML] The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental …
Y Shan, S Tan, Y Lin, S Liao, B Zhang, X Chen… - Journal of …, 2019 - Springer
Background Preserving the integrity of the blood-brain barrier (BBB) is beneficial to avoid
further brain damage after acute ischemic stroke (AIS). Astrocytes, an important component …
further brain damage after acute ischemic stroke (AIS). Astrocytes, an important component …
Astragaloside IV protects against focal cerebral ischemia/reperfusion injury correlating to suppression of neutrophils adhesion-related molecules
M Li, YZ Qu, ZW Zhao, SX Wu, YY Liu, XY Wei… - Neurochemistry …, 2012 - Elsevier
Inflammation injury plays a key role in the process of cerebral injury induced by
ischemia/reperfusion (I/R). Thus, we studied the potential of astragaloside IV, one of the …
ischemia/reperfusion (I/R). Thus, we studied the potential of astragaloside IV, one of the …
Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes
T Nakase, G Söhl, M Theis, K Willecke… - The American journal of …, 2004 - Elsevier
Astrocytes secrete cytokines and neurotrophic factors to neurons, consistent with a
neurosupportive role for astrocytes. However, in ischemic or metabolic insults, the function of …
neurosupportive role for astrocytes. However, in ischemic or metabolic insults, the function of …
[HTML][HTML] Gap junction intercellular communication mediated by connexin43 in astrocytes is essential for their resistance to oxidative stress
HT Le, WC Sin, S Lozinsky, J Bechberger… - Journal of Biological …, 2014 - ASBMB
Oxidative stress induced by reactive oxygen species (ROS) is associated with various
neurological disorders including aging, neurodegenerative diseases, as well as traumatic …
neurological disorders including aging, neurodegenerative diseases, as well as traumatic …