Advances in biotechnology to treat and cure human disease have markedly improved
human health and the development of modern societies. However, substantial challenges …

The significance of extracellular DNA (eDNA) in biofilms was overlooked until researchers
added DNAse to a Pseudomonas aeruginosa biofilm and watched the biofilm disappear …

Highlights•eDNA is a key component of the biofilm matrix of most bacteria.•DNase inhibits
biofilm formation and disperses young biofilms.•DNase treatment can sensitize biofilms to …

Bacteria adhere to natural and engineered surfaces and develop into mature biofilms
encased in self‐produced extracellular polymeric substances (EPSs). EPS consists of …

After the first ancient studies on microbial slime (the name by which the biofilm matrix was
initially indicated), multitudes of studies on the morphology, composition and physiology of …

Extracellular DNA (eDNA) is a macromolecule copiously found in various natural
microenvironments, but its origin and significance still remain partly mysterious phenomena …

Bacteria that cause chronic and/or recurrent diseases often rely on a biofilm lifestyle. The
foundation of the biofilm structure is the extracellular polymeric substance (EPS) that acts as …

We developed a new approach that couples Southwestern blotting and mass spectrometry
to discover proteins that bind extracellular DNA (eDNA) in bacterial biofilms. Using …

Biofilms are community architectures adopted by bacteria inclusive of a self-formed
extracellular matrix that protects resident bacteria from diverse environmental stresses and …

Staphylococcus aureus is an important human pathogen that can form biofilms on various
surfaces. These cell communities are protected from the environment by a self-produced …