Considerable advancements have been made in the quantification of biofluid-based
biomarkers for traumatic brain injury (TBI), which provide a clinically accessible window to …

Traumatic brain injury (TBI) is an injury to the brain caused by an external mechanical force,
affecting millions of people worldwide. The disease course and prognosis are often …

Background Neurotrauma or injuries to the central nervous system (CNS) are a serious
public health problem worldwide. Approximately 75% of all traumatic brain injuries (TBIs) …

Emerging evidence suggests that biofluid-based biomarkers have diagnostic and prognostic
potential in traumatic brain injuries (TBI). However, owing to the lack of a conceptual …

Introduction: Traumatic brain injury (TBI) is a major worldwide neurological disorder of
epidemic proportions. To date, there are still no FDA-approved therapies to treat any forms …

Diagnostic and prognostic biomarkers for mild traumatic brain injury (TBI), also known as
concussion, remain a major unmet clinical need. Moderate to severe TBI can be diagnosed …

Primary objective: The purpose of this paper is to review the clinical and research utility and
applications of blood, cerebrospinal fluid (CSF), and cerebral microdialysis biomarkers in …

Traumatic brain injury (TBI) is one of the leading causes of death and disability around the
world. The lack of validated biomarkers for TBI is a major impediment to developing effective …

Blood-based biomarkers for traumatic brain injury (TBI) have been investigated and
proposed for decades, yet the current clinical assessment of TBI is largely based on clinical …

There has been an explosion of research into biofluid (blood, cerebrospinal fluid, CSF)-
based protein biomarkers in traumatic brain injury (TBI) over the past decade. The …