Research suggests that disproportionate exposure to risk factors places American Indian
(AI) peoples at higher risk for substance use disorders (SUD). Although SUD is linked to …

Substance use disorder is characterized by a transition from volitional to compulsive
responding for drug reward. A possible explanation for this transition may be that alcohol …

Background and aims Dysfunction of the striatum, a brain region part of the mesolimbic
reward system, is a key characteristic of addictive disorders, but neuroimaging studies have …

Rationale Dopamine (DA) in the ventral striatum (VST) has long been implicated in addiction
pathologies, yet its role in temporal decision-making is not well-understood. Objectives To …

Background: Dysregulated ventral striatum function has been proposed as one important
process occurring in individuals with substance use disorder. This study investigates the role …

Background Alcohol use disorder (AUD) is associated with exaggerated preference for
immediate rewards, a candidate endophenotype for use disorders. Addiction symptomology …

Background The relationship between alcohol use and metabolism has focused on the
effects of alcohol use on metabolic factors. Metabolic factors, such as triglycerides …

Background Drug addiction and dependence continue as an unresolved source of morbidity
and mortality. Two approaches to identifying risk for abuse and addiction are …

One well-known phenotypic risk factor for the development of alcohol use disorder is
sensitivity to the rewarding effects of alcohol. In the present study, we examined whether …

Discounting future outcomes as a function of their deferred availability underlies much of
human decision making. Discounting, or preference for immediate over delayed rewards of …