Design and characterization of a fusion glycoprotein vaccine for Respiratory Syncytial Virus with improved stability

L Zhang, E Durr, JD Galli, S Cosmi, PJ Cejas, B Luo… - Vaccine, 2018 - Elsevier
Abstract Respiratory Syncytial Virus (RSV) infection is the leading cause of lower respiratory
tract infection in both young children and older adults. Currently, there is no licensed vaccine …

Stability characterization of a vaccine antigen based on the respiratory syncytial virus fusion glycoprotein

JA Flynn, E Durr, R Swoyer, PJ Cejas, MS Horton… - PLoS …, 2016 - journals.plos.org
Infection with Respiratory Syncytial Virus (RSV) causes both upper and lower respiratory
tract disease in humans, leading to significant morbidity and mortality in both young children …

Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine

Y Che, AV Gribenko, X Song, LD Handke… - Science Translational …, 2023 - science.org
Respiratory syncytial virus (RSV) is the leading, global cause of serious respiratory disease
in infants and is an important cause of respiratory illness in older adults. No RSV vaccine is …

Development of a high yielding bioprocess for a pre-fusion RSV subunit vaccine

P Chen, M Chen, A Menon, AI Hussain, E Carey… - Journal of …, 2021 - Elsevier
Respiratory syncytial virus (RSV) is a highly contagious virus causing severe infection in
infants and the elderly. Various approaches are being used to develop an effective RSV …

2755. Phase 1/2, First-in-Human Study of the Safety, Tolerability, and Immunogenicity of an RSV Prefusion F-Based Subunit Vaccine Candidate.

B Schmoele-Thoma, AR Falsey… - Open Forum …, 2019 - search.ebscohost.com
Background The respiratory syncytial virus (RSV) fusion glycoprotein (F) is a molecule that
fuses the viral and host cell membranes during virus entry as it rearranges from a meta …

Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus

JS McLellan, M Chen, MG Joyce, M Sastry… - science, 2013 - science.org
Respiratory syncytial virus (RSV) is the leading cause of hospitalization for children under 5
years of age. We sought to engineer a viral antigen that provides greater protection than …

A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism

A Krarup, D Truan, P Furmanova-Hollenstein… - Nature …, 2015 - nature.com
Respiratory syncytial virus (RSV) causes acute lower respiratory tract infections and is the
leading cause of infant hospitalizations. Recently, a promising vaccine antigen based on the …

Vaccine development for respiratory syncytial virus

BS Graham - Current opinion in Virology, 2017 - Elsevier
Highlights•RSV is an important cause of lower respiratory tract infection and disease at the
extremes of age.•The RSV fusion (F) glycoprotein is the major target for virus neutralizing …

A novel RSV F-Fc fusion protein vaccine reduces lung injury induced by respiratory syncytial virus infection

Y Zhang, Z Zhou, SL Zhu, X Zu, Z Wang, L Zhang… - Antiviral Research, 2019 - Elsevier
Respiratory syncytial virus (RSV) infection causes significant disease in the lower respiratory
tract of young children, and there is currently no licensed vaccine to prevent RSV infection …

Comparison of immune responses to different versions of VLP associated stabilized RSV pre-fusion F protein

LM Cullen, MR Schmidt, GM Torres, AA Capoferri… - Vaccines, 2019 - mdpi.com
Efforts to develop a vaccine for respiratory syncytial virus (RSV) have primarily focused on
the RSV fusion protein. The pre-fusion conformation of this protein induces the most potent …