Repurposing some older drugs that cross the blood–brain barrier and have potential anticancer activity to provide new treatment options for glioblastoma
D Rundle‐Thiele, R Head, L Cosgrove… - British journal of …, 2016 - Wiley Online Library
Glioblastoma is a brain neoplasm with limited 5‐year survival rates. Developments of new
treatment regimens that improve patient survival in patients with glioblastoma are needed. It …
treatment regimens that improve patient survival in patients with glioblastoma are needed. It …
Repurposing drugs for glioblastoma: from bench to bedside
Glioblastoma multiforme is the most common, aggressive and lethal type of brain tumor. It is
a stage IV cancer disease with a poor prognosis, as the current therapeutic options (surgery …
a stage IV cancer disease with a poor prognosis, as the current therapeutic options (surgery …
[HTML][HTML] An alternative pipeline for glioblastoma therapeutics: a systematic review of drug repurposing in glioblastoma
SB Lyne, B Yamini - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma is a devastating malignancy that has continued to prove
resistant to a variety of therapeutics. No new systemic therapy has been approved for use …
resistant to a variety of therapeutics. No new systemic therapy has been approved for use …
Repurposing existing agents as adjunct therapies for glioblastoma
B Purow - Neuro-Oncology Practice, 2016 - academic.oup.com
Numerous non-oncologic medications have been found in the last decade to have anti-
cancer properties. While the focus in oncology research should clearly remain on deriving …
cancer properties. While the focus in oncology research should clearly remain on deriving …
[HTML][HTML] Drug repurposing, a fast-track approach to develop effective treatments for glioblastoma
I Ntafoulis, SLW Koolen, S Leenstra, MLM Lamfers - Cancers, 2022 - mdpi.com
Simple Summary Introducing novel and effective treatments against glioblastoma (GBM)
remains an arduous journey as reflected in the negative outcome of most clinical trials. The …
remains an arduous journey as reflected in the negative outcome of most clinical trials. The …
Pharmacotherapies for the treatment of glioblastoma–current evidence and perspectives
K Seystahl, D Gramatzki, P Roth… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Glioblastoma, the most common malignant brain tumor, exhibits a poor
prognosis with little therapeutic progress in the last decade. Novel treatment strategies …
prognosis with little therapeutic progress in the last decade. Novel treatment strategies …
[HTML][HTML] Drug repurposing for the treatment of glioblastoma multiforme
C Abbruzzese, S Matteoni, M Signore… - Journal of Experimental …, 2017 - Springer
Abstract Background Glioblastoma Multiforme is the deadliest type of brain tumor and is
characterized by very poor prognosis with a limited overall survival. Current optimal …
characterized by very poor prognosis with a limited overall survival. Current optimal …
[HTML][HTML] New directions in the therapy of glioblastoma
K Szklener, M Mazurek, M Wieteska, M Wacławska… - Cancers, 2022 - mdpi.com
Simple Summary Despite the continuous development of treatment technology,
glioblastoma remains a challenge for modern medicine. The standard of care remains a …
glioblastoma remains a challenge for modern medicine. The standard of care remains a …
Pharmacological strategies for improving the prognosis of glioblastoma
Introduction: Treatments for brain cancer have radically evolved in the past decade due to a
better understanding of the interplay between the immune system and tumors of the central …
better understanding of the interplay between the immune system and tumors of the central …
[HTML][HTML] Blood–brain barrier crossing and breakthroughs in glioblastoma therapy
P Sminia, BA Westerman - British journal of clinical pharmacology, 2016 - ncbi.nlm.nih.gov
Glioblastoma is a heterogeneous tumour type which is highly resistant to radiotherapy and
chemotherapy. Clinical results following standard therapy as well as new approaches using …
chemotherapy. Clinical results following standard therapy as well as new approaches using …
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