Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions
The safety and efficacy of kratom (Mitragyna speciosa) for treatment of pain is highly
controversial. Kratom produces more than 40 structurally related alkaloids, but most studies …
controversial. Kratom produces more than 40 structurally related alkaloids, but most studies …
Metabolism of a kratom alkaloid metabolite in human plasma increases its opioid potency and efficacy
Kratom is widely consumed in the United States for self-treatment of pain and opioid
withdrawal symptoms. Mitragynine is the most abundant alkaloid in kratom and is a μ-opioid …
withdrawal symptoms. Mitragynine is the most abundant alkaloid in kratom and is a μ-opioid …
7-Hydroxymitragynine is an active metabolite of mitragynine and a key mediator of its analgesic effects
AC Kruegel, R Uprety, SG Grinnell… - ACS central …, 2019 - ACS Publications
Mitragyna speciosa, more commonly known as kratom, is a plant native to Southeast Asia,
the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for …
the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for …
Clinical Pharmacokinetic Assessment of Kratom (Mitragyna speciosa), a Botanical Product with Opioid-like Effects, in Healthy Adult Participants
RS Tanna, JT Nguyen, DL Hadi, PK Manwill… - Pharmaceutics, 2022 - mdpi.com
Increasing use of the botanical kratom to self-manage opioid withdrawal and pain has led to
increased kratom-linked overdose deaths. Despite these serious safety concerns, rigorous …
increased kratom-linked overdose deaths. Despite these serious safety concerns, rigorous …
The medicinal chemistry and neuropharmacology of kratom: A preliminary discussion of a promising medicinal plant and analysis of its potential for abuse
AC Kruegel, O Grundmann - Neuropharmacology, 2018 - Elsevier
The leaves of Mitragyna speciosa (commonly known as kratom), a tree endogenous to parts
of Southeast Asia, have been used traditionally for their stimulant, mood-elevating, and …
of Southeast Asia, have been used traditionally for their stimulant, mood-elevating, and …
Update on the pharmacology and legal status of kratom
WC Prozialeck - Journal of Osteopathic Medicine, 2016 - degruyter.com
Kratom (Mitragyna speciosa) is a plant indigenous to Southeast Asia. Its leaves and the teas
brewed from them have long been used by people in that region to stave off fatigue and to …
brewed from them have long been used by people in that region to stave off fatigue and to …
[HTML][HTML] Understanding kratom use: a guide for healthcare providers
Kratom (Mitragyna speciosa Korth., Rubiaceae) is a plant native to Southeast Asia, where it
has been used for centuries as a mild stimulant and as medicine for various ailments. More …
has been used for centuries as a mild stimulant and as medicine for various ailments. More …
Oxidative metabolism as a modulator of kratom's biological actions
S Chakraborty, R Uprety, ST Slocum, T Irie… - Journal of medicinal …, 2021 - ACS Publications
The leaves of Mitragyna speciosa (kratom), a plant native to Southeast Asia, are increasingly
used as a pain reliever and for attenuation of opioid withdrawal symptoms. Using the tools of …
used as a pain reliever and for attenuation of opioid withdrawal symptoms. Using the tools of …
Pharmacokinetics of eleven kratom alkaloids following an oral dose of either traditional or commercial kratom products in rats
SH Kamble, EC Berthold, TI King… - Journal of natural …, 2021 - ACS Publications
Kratom, Mitragyna speciosa Korth., is being widely consumed in the United States for pain
management and the reduction of opioid withdrawal symptoms. The central nervous system …
management and the reduction of opioid withdrawal symptoms. The central nervous system …
Pharmacology of kratom: an emerging botanical agent with stimulant, analgesic and opioid-like effects
WC Prozialeck, JK Jivan, SV Andurkar - Journal of Osteopathic …, 2012 - degruyter.com
Kratom (Mitragyna speciosa) is a plant indigenous to Thailand and Southeast Asia. Kratom
leaves produce complex stimulant and opioid-like analgesic effects. In Asia, kratom has …
leaves produce complex stimulant and opioid-like analgesic effects. In Asia, kratom has …
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