The antiviral innate immunity is the first line of host defense against virus infections. In
mammalian cells, viral infections initiate the expression of interferons (IFNs) in the host that …

Abstract Interferon-alpha (IFN-α) is a potent anti-viral cytokine, critical to the host immune
response against viruses. IFN-α is first produced upon viral detection by pathogen …

Viruses commonly antagonize the antiviral type I interferon response by targeting signal
transducer and activator of transcription 1 (STAT1) and STAT2, key mediators of interferon …

To evade immunity, many viruses express interferon antagonists that target STAT
transcription factors as a major component of pathogenesis. Because of a lack of direct …

The intracellular innate antiviral response in human cells is an essential component of
immunity against virus infection. As obligate intracellular parasites, all viruses must evade …

The type I and II interferons (IFNs) are potent stimulators of antigen processing and
presentation and are essential in antiviral immunity. IFNs upregulate the transcription of …

Interferons (IFN) s are involved in numerous immune interactions during viral infections and
contribute to both induction and regulation of innate and adaptive antiviral mechanisms …

The signal transducer and activator of transcription (STAT) family proteins are essential
mediators of cytokine and growth factor functions. The interferon (IFN) family of cytokines is …

The actions of type I interferons (IFNs) provide our first barrier of defense against virus
infection and are the foundation of innate immunity. Upon virus infection host pathogen …

Interferons are a group of small proteins that play key roles in host antiviral innate immunity.
Their induction mainly relies on host pattern recognition receptors (PRR). Host PRR for RNA …