α (N)-Heterocyclic thiosemicarbazones: iron chelators that are promising for revival of gallium in cancer chemotherapy
S Cao, X Chen, L Chen, J Chen - Anti-Cancer Agents in …, 2016 - ingentaconnect.com
The metal-based drugs have gained increasing attention in the fight against cancer. Ga (III)
in the form of inorganic salts has demonstrated efficacy in the treatment of a number of …
in the form of inorganic salts has demonstrated efficacy in the treatment of a number of …
Gallium (III) and iron (III) complexes of α-N-heterocyclic thiosemicarbazones: synthesis, characterization, cytotoxicity, and interaction with ribonucleotide reductase
CR Kowol, R Berger, R Eichinger, A Roller… - Journal of medicinal …, 2007 - ACS Publications
A series of gallium (III) and iron (III) complexes with five different 4N-substituted α-N-
heterocyclic thiosemicarbazones, viz., 2-acetylpyridine N, N-dimethylthiosemicarbazone (1) …
heterocyclic thiosemicarbazones, viz., 2-acetylpyridine N, N-dimethylthiosemicarbazone (1) …
Iron-Targeting Antitumor Activity of Gallium Compounds and Novel Insights Into Triapine®-Metal Complexes
CR Chitambar, WE Antholine - Antioxidants & redox signaling, 2013 - liebertpub.com
Significance: Despite advances made in the treatment of cancer, a significant number of
patients succumb to this disease every year. Hence, there is a great need to develop new …
patients succumb to this disease every year. Hence, there is a great need to develop new …
2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor …
DR Richardson, DS Kalinowski… - Journal of medicinal …, 2009 - ACS Publications
Through systematic structure− activity studies of the 2-benzoylpyridine thiosemicarbazone
(HBpT), 2-(3-nitrobenzoyl) pyridine thiosemicarbazone (HNBpT) and dipyridylketone …
(HBpT), 2-(3-nitrobenzoyl) pyridine thiosemicarbazone (HNBpT) and dipyridylketone …
A Main Group Gallium(III) Complex Derived from 2-Acetylpyrazine N4-phenylthiosemicarbazone: Synthesis, Crystal Structure and Biological Evaluation
Y Lu, P Ma, M Li, D Chen, X Zou - Synthesis and Reactivity in …, 2016 - Taylor & Francis
Up to now, main group gallium (III) complexes with thiosemicarbazones have been
comparatively rare. Here, a main group six-coordinated gallium (III) complex [Ga (L) 2] NO3 …
comparatively rare. Here, a main group six-coordinated gallium (III) complex [Ga (L) 2] NO3 …
Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety
A Mrozek-Wilczkiewicz, K Malarz, M Rejmund… - European Journal of …, 2019 - Elsevier
Thiosemicarbazones (TSC) are a subclass of iron-chelating agents that are believed to have
an anticancer activity. The high potential for the application of this compound class can be …
an anticancer activity. The high potential for the application of this compound class can be …
Interaction of Triapine and related thiosemicarbazones with iron (III)/(II) and gallium (III): a comparative solution equilibrium study
ÉA Enyedy, MF Primik, CR Kowol, VB Arion… - Dalton …, 2011 - pubs.rsc.org
Stoichiometry and stability of GaIII, FeIII, FeII complexes of Triapine and five related α-N
heterocyclic thiosemicarbazones with potential antitumor activity have been determined by …
heterocyclic thiosemicarbazones with potential antitumor activity have been determined by …
Exploiting cancer metal metabolism using anti-cancer metal-binding agents
AM Merlot, DS Kalinowski, Z Kovacevic… - Current Medicinal …, 2019 - ingentaconnect.com
Metals are vital cellular elements necessary for multiple indispensable biological processes
of living organisms, including energy transduction and cell proliferation. Interestingly …
of living organisms, including energy transduction and cell proliferation. Interestingly …
New Stable Gallium (III) and Indium (III) Complexes with Thiosemicarbazone Ligands: A Biological Evaluation
The aim of this work is to explore a new library of coordination compounds for medicinal
applications. Gallium is known for its various applications in this field. Presently, indium is …
applications. Gallium is known for its various applications in this field. Presently, indium is …
The role of iron chelation in cancer therapy
JL Buss, FM Torti, SV Torti - Current medicinal chemistry, 2003 - ingentaconnect.com
This review focuses on advances and strategies in the use of iron chelators as anti-tumor
therapies. Although the development of iron chelators for human disease has focused …
therapies. Although the development of iron chelators for human disease has focused …