Protein synthesis by ribosomes is critically important for gene expression in all cells.
Ribosomal RNAs (rRNAs) are marked by numerous chemical modifications. An abundant …

Ribosomal RNAs (rRNAs) are main effectors of messenger RNA (mRNA) decoding, peptide-
bond formation, and ribosome dynamics during translation. Ribose 2′-O-methylation (2 …

Ribosomal RNA (rRNA) undergoes post-transcriptional modification of over 200 nucleotides,
predominantly 2′-O-methylation (2′-O-Me). 2′-O-Methylation protects RNA from …

Ribosomes are complex ribozymes that interpret genetic information by translating
messenger RNA (mRNA) into proteins. Natural variation in ribosome composition has been …

Eukaryotic rRNAs contain scores of two major types of nucleotide modifications, 2'-O-
methylation (Nm) and pseudouridylation (Ψ). Both types are known to alter the stability and …

In all three domains of life ribosomal RNAs are extensively modified at functionally important
sites of the ribosome. These modifications are believed to fine-tune the ribosome structure …

Chemical modifications of RNA have recently gained new attention in biological sciences.
They occur notably on messenger RNA (mRNA) and ribosomal RNA (rRNA) and are …

Ribosome biogenesis is a complex process, and dozens of factors are required to facilitate
and regulate the subunit assembly in bacteria. The 2′-O-methylation of U2552 in 23S rRNA …

Ribosome heterogeneity is of increasing biological significance and several examples have
been described for multicellular and single cells organisms. In here we show for the first time …

Translational regulation impacts both pluripotency maintenance and cell differentiation. To
what degree the ribosome exerts control over this process remains unanswered …