This study investigated the ability of medium from irradiated cells to induce early events in
the apoptotic cascade, such as mobilization of intracellular calcium, loss of mitochondrial …

The ability of medium from γ-irradiated cells to induce early events in the apoptotic cascade,
such as the mobilization of intracellular calcium, loss of mitochondrial membrane potential …

Genomic instability and the bystander effect have recently been linked experimentally. It has
previously been shown that medium from irradiated cells can induce early events in the …

Cell death may occur by either of two mechanisms: apoptosis or necrosis. Necrosis, the first
type of cell death to be recognized, is an uncontrolled degenerative phenomenon invariably …

The target-cell theory of tissue responses is reviewed with reference to the radiosensitivity of
proposed target cells in bone marrow, intestine, epidermis, and spermatogenesis. The …

Fifteen different murine tumours were evaluated with respect to the degree of apoptosis
development that occurs in the tumour tissue in the first few hours following irradiation in …

We have compared the induction of apoptosis and cytokine release by UVB and γ-radiation
in primary (untransformed) and in two immortalized human epithelial/keratinocyte cell lines …

In recent years, the significance of apoptosis as a process in cell loss from normal tissue and
tumours has been critically reviewed. In addition, the general lack of a correlation between …

Recent studies have suggested a correlation between the rate and incidence of apoptosis
and the radiation response of particular cell lines. However, we found that increasing the …

Apoptosis is not as dominant a process in cell loss from normal tissues and tumours as has
sometimes been claimed. The term'programmed cell death', which many authors regard as …