Indometacin, an inhibitor of cyclooxygenase-2 (COX-2), has been shown to exert anticancer
effects in a variety of cancers. However, the effect and mechanism of indometacin on high …

The relationship between diabetes mellitus and pancreatic cancer is complex. Diabetes has
been postulated to be both an independent risk factor and a consequence of pancreatic …

Increasing evidence indicates that pancreatic stellate cells (PSCs) are responsible for the
stromal reaction in pancreatic ductal adenocarcinoma (PDAC). The interaction between …

Diabetes mellitus and pancreatic cancer are intimately related, as approximately 85% of
pancreatic cancer patients suffer from glucose intolerance or even diabetes. In this study, we …

Diabetes mellitus (DM) is associated with an increased risk of colorectal cancer (CRC).
Hyperglycemia, a chronic abnormality in diabetes, is an independent predictor of cancer …

The progression of colorectal cancer has been reported to have a positive correlation with
the combination of hyperglycemia and hyperinsulinemia in diabetic patients, leading to a …

Epithelial-mesenchymal transition (EMT), which is mainly recognized by upregulation of
mesenchymal markers and movement of cells, is a critical stage occurred during embryo …

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with
high invasive and metastatic potential. We generated a spontaneous PDAC mouse model …

Objectives Hyperinsulinemia is a risk factor for pancreatic cancer, but the function of insulin
in carcinogenesis is unclear, so this study aimed to elucidate the carcinogenic effects of …

Cell–cell adhesion plays an important role in regulation of cell proliferation, migration,
survival, and drug sensitivity. Metformin, a first line drug for type 2 diabetes, has been shown …