[HTML][HTML] Diagnostic value of one-step nucleic acid amplification for sentinel lymph node metastasis in cytokeratin 19-positive tumors: evidence from bioinformatics and …

K Li, M Meng, W Zhang, J Li, Y Wang… - Frontiers in …, 2024 - ncbi.nlm.nih.gov
Background The status of the sentinel lymph nodes (SLNs) was an important prognostic
factor in varies cancers. A one-step nucleic acid amplification (OSNA) assay, a molecular …

The performance of one-step nucleic acid amplification assay for intraoperative detection of sentinel lymph node macrometastasis in breast cancer: An updated meta …

F Shi, Z Liang, Q Zhang, C Wang, X Liu - The Breast, 2018 - Elsevier
Background One-step nucleic acid amplification (OSNA) assay is a molecular diagnostic
method for intraoperative detection of lymph node metastasis by amplifying cytokeratin 19 …

One-step nucleic acid amplification assay for intraoperative prediction of advanced axillary lymph node metastases in breast cancer patients with sentinel lymph node …

M Kubota, Y Komoike, M Hamada… - Molecular and …, 2016 - spandidos-publications.com
The one-step nucleic acid amplification (OSNA) assay is used to semiquantitatively measure
the cytokeratin (CK) 19 mRNA copy numbers of each sentinel lymph node (SLN) in breast …

One-step nucleic acid amplification can identify sentinel node-negative breast cancer patients with excellent prognosis

K Shimazu, T Miyake, JUN Okuno, Y Naoi… - Anticancer …, 2019 - ar.iiarjournals.org
Background/Aim: One-step nucleic acid amplification (OSNA) is a newly developed
procedure for detection of node metastasis by targeting CK19 mRNA. This study aimed to …

[HTML][HTML] Sentinel node tumour burden quantified based on cytokeratin 19 mRNA copy number predicts non-sentinel node metastases in breast cancer: Molecular …

T Osako, T Iwase, K Kimura, R Horii… - European Journal of …, 2013 - Elsevier
OBJECTIVE: The one-step nucleic acid amplification (OSNA) assay can assess an entire
lymph node and detect clinically relevant metastases quantified based on cytokeratin 19 …

One-step nucleic acid amplification (OSNA): where do we go with it?

Y Tamaki - International journal of clinical oncology, 2017 - Springer
The one-step nucleic acid amplification (OSNA) assay was initially developed for the
intraoperative assessment of sentinel lymph node metastases in breast cancer. This assay …

One-step nucleic acid amplification in breast cancer sentinel lymph node: A single institutional experience and a short review

T Brambilla, B Fiamengo, C Tinterri, A Testori… - Frontiers in …, 2015 - frontiersin.org
Sentinel lymph node (SLN) examination is a standard in breast cancer patients, with several
methods employed along its 20 years history, the last one represented by one-step nucleic …

A cut-off of 2150 cytokeratin 19 mRNA copy number in sentinel lymph node may be a powerful predictor of non-sentinel lymph node status in breast cancer patients

I Terrenato, V D'Alicandro, B Casini, L Perracchio… - PLoS …, 2017 - journals.plos.org
Since 2007, one-step nucleic acid amplification (OSNA) has been used as a diagnostic
system for sentinel lymph node (SLN) examination in patients with breast cancer. This study …

Molecular detection of lymph node metastases in breast cancer patients: results of a multicenter trial using the one-step nucleic acid amplification assay

Y Tamaki, F Akiyama, T Iwase, T Kaneko, H Tsuda… - Clinical Cancer …, 2009 - AACR
Purpose: Accurate assessment of metastasis in sentinel lymph nodes (SLN) of breast cancer
is important but involves a heavy workload for the pathologist. We conducted a multicenter …

A novel automated assay for the rapid identification of metastatic breast carcinoma in sentinel lymph nodes

S Feldman, S Krishnamurthy, W Gillanders… - Cancer, 2011 - Wiley Online Library
BACKGROUND: The authors prospectively evaluated the performance of a proprietary
molecular testing platform using one‐step nucleic acid amplification (OSNA) for the …