Thirty per cent of all colorectal tumours develop in the rectum. The location of the rectum
within the bony pelvis and its proximity to vital structures presents significant therapeutic …

In rectal cancer treatment, attention has focused on the local primary tumour and the
regional tumour cell deposits to diminish the risk of a loco-regional recurrence. Several large …

Background Although neoadjuvant radiotherapy may improve local control of rectal cancer,
its clinical value requires further evaluation as a result of potential side effects and advances …

Neoadjuvant chemoradiotherapy has become the standard treatment for locally advanced
rectal cancer. Neoadjuvant chemoradiotherapy not only can reduce tumor size and …

BACKGROUND: The optimal type of neoadjuvant therapy regimen in rectal cancer is
contentious. OBJECTIVE: This study aimed to review the impact of neoadjuvant therapy on …

Purpose This guideline reviews the evidence and provides recommendations for the
indications and appropriate technique and dose of neoadjuvant radiation therapy (RT) in the …

The management of rectal cancer has evolved significantly in the last few decades.
Significant improvements in local disease control were achieved in the 1990s, with the …

PURPOSE We investigated whether neoadjuvant chemoradiotherapy (nCRT) in patients
with rectal cancer can be restricted to those at high risk of locoregional recurrence (LR) …

Objective To examine clinical outcomes in patients receiving neoadjuvant chemoradiation
for locally advanced rectal adenocarcinoma. Summary Background Data Preoperative …

A neoadjuvant multimodality approach with chemoradiation therapy (CRT) is the preferred
treatment strategy for most distal rectal cancers. Significant downstaging and complete …