Shared genetic links between frontotemporal dementia and psychiatric disorders

C Li, D Pang, J Lin, T Yang, H Shang - BMC medicine, 2022 - Springer
Background Epidemiological and clinical studies have suggested comorbidity between
frontotemporal dementia (FTD) and psychiatric disorders. FTD patients carrying specific …

Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases

R Ferrari, Y Wang, J Vandrovcova, S Guelfi… - Journal of Neurology …, 2017 - jnnp.bmj.com
Background Clinical, pathological and genetic overlap between sporadic frontotemporal
dementia (FTD), Alzheimer's disease (AD) and Parkinson's disease (PD) has been …

[HTML][HTML] Gene expression imputation across multiple tissue types provides insight into the genetic architecture of frontotemporal dementia and its clinical subtypes

LM Reus, B Pasaniuc, D Posthuma, T Boltz, R Ferrari… - Biological …, 2021 - Elsevier
Background The etiology of frontotemporal dementia (FTD) is poorly understood. To identify
genes with predicted expression levels associated with FTD, we integrated summary …

The relationship between schizophrenia and frontotemporal dementia

JJ Cooper, F Ovsiew - Journal of Geriatric Psychiatry and …, 2013 - journals.sagepub.com
Schizophrenia is a relatively common disorder diagnosed by the presentation of psychotic
symptoms in the absence of identifiable neurologic or other organic cause. Frontotemporal …

Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies

I Broce, CM Karch, N Wen, CC Fan, Y Wang… - PLoS …, 2018 - journals.plos.org
Background Converging evidence suggests that immune-mediated dysfunction plays an
important role in the pathogenesis of frontotemporal dementia (FTD). Although genetic …

Frontotemporal dementia and its subtypes: a genome-wide association study

R Ferrari, DG Hernandez, MA Nalls, JD Rohrer… - The Lancet …, 2014 - thelancet.com
Background Frontotemporal dementia (FTD) is a complex disorder characterised by a broad
range of clinical manifestations, differential pathological signatures, and genetic variability …

Distinct neuroanatomical correlates of neuropsychiatric symptoms in the three main forms of genetic frontotemporal dementia in the GENFI cohort

L Sellami, M Bocchetta, M Masellis… - Journal of …, 2018 - content.iospress.com
Background: The overlap between frontotemporal dementia (FTD) and primary psychiatric
disorders has been brought to light by reports of prominent neuropsychiatric symptoms …

Genome-wide association study of frontotemporal dementia identifies a C9ORF72 haplotype with a median of 12-G4C2 repeats that predisposes to pathological …

LM Reus, IE Jansen, MO Mol, F van Ruissen… - Translational …, 2021 - nature.com
Genetic factors play a major role in frontotemporal dementia (FTD). The majority of FTD
cannot be genetically explained yet and it is likely that there are still FTD risk loci to be …

Clinico-genetic findings in 509 frontotemporal dementia patients

M Wagner, G Lorenz, AE Volk, T Brunet… - Molecular …, 2021 - nature.com
Frontotemporal dementia (FTD) is a clinically and genetically heterogeneous disorder. To
which extent genetic aberrations dictate clinical presentation remains elusive. We …

Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA …

E Taskesen, A Mishra, S van der Sluis, R Ferrari… - Scientific reports, 2017 - nature.com
Frontotemporal dementia (FTD) is a neurodegenerative disorder predominantly affecting the
frontal and temporal lobes. Genome-wide association studies (GWAS) on FTD identified …