Arsenic induces polyadenylation of canonical histone mRNA by down-regulating stem-loop-binding protein gene expression
The replication-dependent histone genes are the only metazoan genes whose messenger
RNA (mRNA) does not terminate with a poly (A) tail at the 3′-end. Instead, the histone …
RNA (mRNA) does not terminate with a poly (A) tail at the 3′-end. Instead, the histone …
A potential new mechanism of arsenic carcinogenesis: depletion of stem-loop binding protein and increase in polyadenylated canonical histone H3. 1 mRNA
Canonical histones are synthesized with a peak in S-phase, whereas histone variants are
formed throughout the cell cycle. Unlike messenger RNA (mRNA) for all other genes with a …
formed throughout the cell cycle. Unlike messenger RNA (mRNA) for all other genes with a …
Polyadenylation of histone H3. 1 mRNA promotes cell transformation by displacing H3. 3 from gene regulatory elements
Replication-dependent canonical histone messenger RNAs (mRNAs) do not terminate with
a poly (A) tail at the 3′ end. We previously demonstrated that exposure to arsenic, an …
a poly (A) tail at the 3′ end. We previously demonstrated that exposure to arsenic, an …
Review of arsenic toxicity, speciation and polyadenylation of canonical histones
M Costa - Toxicology and applied pharmacology, 2019 - Elsevier
Arsenic contamination impacts hundreds of millions of people in the world. Arsenic is a well-
established human carcinogen and has been shown to cause skin, lung, bladder, liver …
established human carcinogen and has been shown to cause skin, lung, bladder, liver …
Stem-loop binding protein and metal carcinogenesis
BR Bradford, C Jin - Seminars in cancer biology, 2021 - Elsevier
Pre-mRNA processing of the replication-dependent canonical histone mRNAs requires an
endonucleolytic cleavage immediately after a conserved stem loop structure which occurs …
endonucleolytic cleavage immediately after a conserved stem loop structure which occurs …
Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts
J Li, M Gorospe, J Barnes, Y Liu - Journal of Biological Chemistry, 2003 - ASBMB
Although epidemiological studies have long established that inorganic arsenic is a potent
human carcinogen, the underlying mechanisms are still poorly understood. Recent studies …
human carcinogen, the underlying mechanisms are still poorly understood. Recent studies …
Arsenite alters global histone H3 methylation
Arsenic (As) is a well-characterized human carcinogen but is generally not mutagenic. The
evidence that As induces both loss of global DNA methylation and gene promoter DNA …
evidence that As induces both loss of global DNA methylation and gene promoter DNA …
Influence of arsenic on global levels of histone posttranslational modifications: a review of the literature and challenges in the field
CG Howe, MV Gamble - Current environmental health reports, 2016 - Springer
Arsenic is a human carcinogen and also increases the risk for non-cancer outcomes.
Arsenic-induced epigenetic dysregulation may contribute to arsenic toxicity. Although there …
Arsenic-induced epigenetic dysregulation may contribute to arsenic toxicity. Although there …
Arsenic trioxide reduces global histone H4 acetylation at lysine 16 through direct binding to histone acetyltransferase hMOF in human cells
D Liu, D Wu, L Zhao, Y Yang, J Ding, L Dong, L Hu… - PLoS …, 2015 - journals.plos.org
Histone post-translational modification heritably regulates gene expression involved in most
cellular biological processes. Experimental studies suggest that alteration of histone …
cellular biological processes. Experimental studies suggest that alteration of histone …
Epigenetic targets of arsenic: emphasis on epigenetic modifications during carcinogenesis
ABSTRACT DNA methylation and histone modification promote opening and closure of
chromatin structure, which affects gene expression without altering the DNA sequence …
chromatin structure, which affects gene expression without altering the DNA sequence …