Lysosomes play a vital role in the maintenance of cellular homeostasis through the recycling
of cell constituents, a key metabolic function which is highly dependent on the correct …

Lysosomes play a vital role in the maintenance of cellular homeostasis through the recycling
of cell constituents, a key metabolic function which is highly dependent on the correct …

Lysosomal storage disorders (LSDs) comprise a broad disease group of inherited metabolic
disorders, the majority of which are associated with CNS pathology, significant disability and …

Lysosomes, with their arsenal of catabolic enzymes and crucial metabolic housekeeping
functions are experiencing a revived research interest after having lived a rather quiet life for …

Introduction: The success of the first enzyme replacement therapy (ERT) for a lysosomal
storage disease (LSD) and the regulatory and commercial incentives provided by authorities …

The past three decades of enzyme therapy (ET) for lysosomal storage diseases (LSDs) have
been life-saving and have improved lives of many affected individuals and their families. The …

This special topic issue published in the journal Current Pharmaceutical Biotechnology is
devoted to Recent advances in treatment approaches of lysosomal storage diseases …

Lysosomes were discovered more than five decades ago and characterized as cytoplasmic
organelles loaded with acid hydrolases responsible for the digestion of macromolecules and …

Genetic mutations that cause specific lysosomal protein deficiencies account for more than
45 Lysosomal Storage Diseases (LSDs), mostly pre-adult disorders which are associated …

Lysosomes are ubiquitous, acidic intracellular compartments that fulfil a crucial role in
degradation of macromolecules in cells. Specific lysosomal catabolic reactions may be …