Owing to the specific molecular structure of surfactants, these compounds can penetrate into
the stratum corneum (SC) and thereby increase the transdermal absorption of drugs. As a …

Surfactants are found in many existing therapeutic, cosmetic, and agro-chemical
preparations. In recent years, surfactants have been employed to enhance the permeation …

Chemical penetration enhancers have been studied for a long time as a means to increase
the transport of a drug across the skin barrier. They exert their effect by using a range of …

Transdermal delivery systems have been intensively studied over the past 2 decades, with
the focus on overcoming the skin barrier for more effective application of pharmaceutical and …

There is considerable interest in the skin as a site of drug application both for local and
systemic effect. However, the skin, in particular the stratum corneum, poses a formidable …

The highly organized structure of the stratum corneum provides an effective barrier to the
drug delivery into or across the skin. To overcome this barrier function, penetration …

Transdermal drug delivery has been accepted as a potential noninvasive route of drug
administration, with advantages of prolonged therapeutic action, decreased side effect, easy …

Transdermal drug delivery has attracted considerable attention over the past 2-3 decades in
regard of its many potential advantages. However, the role of the skin as a protective barrier …

Transdermal drug delivery is a passive diffusion process of an active compound through the
skin which is affected by drug solubility in the multilamellar lipidic matrix of the stratum …

In its first part, this review paper discusses skin morphology and barrier function of the
stratum corneum for drug permeation after its transdermal administration or topical …