Two major medical applications have inspired this thesis: firstly, the potential link between
the venous circulation and several neurological pathologies, secondly arterial hypertension …

This paper presents a mathematical model of the global, arterio‐venous circulation in the
entire human body, coupled to a refined description of the cerebrospinal fluid (CSF) …

In this paper we describe a model of the human intracranial space which is extended with
the vascular system. We focus on a detailed modelling of the coupling between cerebral …

Most attempts to study intracranial pressure using lumped-parameter models have adopted
the classical``Kellie-Monro Doctrine,''which considers the intracranial space to be a closed …

Abstract Behind Medicine (M) is Physiology (P), behind Physiology is Physics (P) and
behind Physics is always Mathematics (M), for which I expect that the symmetry of the …

The pulsatile nature of the CSF movement is a result of the cardiac-related pulsations in
blood volume in cranial region. According to Monro–Kellie Doctrine, the net inflow of arterial …

The cerebrospinal fluid (CSF) fills the ventricles, the cranial and spinal subarachnoid
spaces. CSF exhibits a pulsatile motion essential to normal brain function and its flow …

A mathematical model of the isolated intracranial system including autoregulation of
cerebral blood flow with the aid of a variable cerebrovascular resistance is described. The …

Background The role of vascular abnormalities in the onset and course of neurological
diseases has long been recognized. In the last decade, the influence of intra-and …

Here we extend the global, closed-loop, mathematical model for the cardiovascular system
in Müller and Toro (2014) to account for fundamental mechanisms affecting cerebral venous …