The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and
development, and when deregulated makes an important contribution to disease. Here, we …

Preclinical studies in the 1980s defined a role for IGF signaling in the development and
sustainability of the malignant process. Subsequently, antibody, tyrosine kinase, and ligand …

The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently
overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF …

The insulin and insulin-like growth factor (IGF) system plays an important role in regulating
normal cell proliferation and survival. However, the IGF system is also implicated in many …

The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development
and maintenance of cancer. Since the first links between growth factor receptors and …

IGF-I receptor (IGF-IR) signaling and functions are mediated through the activities of a
complex molecular network of positive (eg., type I IGF) and negative (eg., the type II IGF …

Insulin-like growth factor 1 (IGF1) is a polypeptide hormone that has a high degree of
structural similarity to human proinsulin. Owing to its ubiquitous nature and its role in …

Introduction: The insulin-like growth factors (IGFs) are a family of secreted peptide hormones
with important roles in different cellular and organism functions. The biological activities of …

The insulin-like growth factors (IGFs; IGF-1 and IGF-2) play central roles in cell growth,
differentiation, survival, transformation and metastasis. The biologic effects of the IGFs are …

The IGF network of ligands, cell-surface receptors and IGF-binding proteins has important
roles at multiple levels, including the cellular, organ and organism levels. The IGF system …