Insulin-like growth factor (IGF) 1 is a member of a family that is involved in growth,
development, cell differentiation, and metabolism. IGF1, IGF2 and insulin act primarily …

The type 1 insulin-like growth factor receptor (IGF1R) is overexpressed by many tumors, and
mediates growth, motility and protection from apoptosis. Inhibition of IGF1R expression or …

Some cancer cells depend on the function of specific molecules for their growth, survival,
and metastatic potential. Targeting of these critical molecules has arguably been the best …

The type I insulin-like growth factor receptor (IGF1R) is involved in growth and survival of
normal and neoplastic cells. A ligand-dependent conformational change is thought to …

Insulin-like growth factors (IGFs) are mitogenic and anti-apoptotic peptides that influence the
proliferative behavior of many cell types, including normal and transformed breast epithelial …

The importance of insulin-like growth factor 1 receptor (IGF-1R) signalling in malignant
behaviour of tumour cells is well established. Currently, development of drugs targeting the …

Insulin-like growth factor-1 receptor (IGF-1R) is a receptor tyrosine kinase (RTK) and critical
activator of the phosphatidylinositol 3-kinase–AKT pathway. IGF-1R is required for …

Over the past decade, dozens of epidemiological studies and laboratory experiments have
provided evidence for relationships between insulin-like growth factor (IGF) physiology and …

Insulin and insulin-like growth factor (IGF) signaling system, commonly known for fine-tuning
numerous biological processes, has lately made its mark as a much sought-after therapeutic …

Insulin-like growth factor-I receptor (IGF-IR) and its ligands, IGF-I and IGF-II, are up-regulated
in a variety of human cancers. In tumors, such as colorectal, non–small cell lung, ovarian …