Laminin-binding integrin receptors are key mediators of epithelial cell migration and tumor
metastasis. Recent studies have demonstrated a role for the α6 integrin (ITGA6/CD49f) in …

Bone metastasis remains a major cause of mortality and morbidity in breast cancer.
Therefore, there is an urgent need to better select high-risk patients in order to adapt …

Integrins constitute a family of cell surface receptors that are heterodimers composed of
noncovalently associated α and β subunits. Integrins bind to extracellular matrix proteins …

Introduction: Breast cancer is one of the most common malignancies affecting women in the
United States and Europe. Approximately three out of every four women with breast cancer …

Of the estimated 565,650 people in the US who will die of cancer in 2008, almost all will
have metastasis. Breast, prostate, kidney, thyroid and lung cancers metastasize to the bone …

Expression of α6 integrin, a laminin receptor, on tumor cell surfaces is associated with
reduced patient survival and increased metastasis in a variety of tumors. In prostate cancer …

The reasons why tumor cells metastasize to bone remain obscure. There is some evidence
to support the theory that integrins (acting as cell surface adhesion receptors) play a role in …

Integrin α3β1 promotes tumor cell adhesion, migration, and invasion on laminin isoforms,
and several clinical studies have indicated a correlation between increased tumoral α3β1 …

Tumor-induced bone disease is common among patients with advanced solid cancers,
especially those with breast, prostate, and lung malignancies. The tendency of these …

Osteosarcoma is an aggressive bone cancer that has a high propensity for metastasis to the
lungs. Patients with metastatic disease face a very poor prognosis. Therefore, novel …