Importance Molecular testing of the presence of pathogenic genomic variants in a tumor
without quantifying the variant allele fraction (VAF) does not differentiate the variation extent …

Importance Interpatient variabilities in genomic variants may reflect differences in tumor
statuses among individuals. Objectives To delineate interpatient variabilities inRASvariants …

THYROID CANCER IS THE NINTH MOST COMMON CAN-cer in the United States, with an
incidence that has been increasing sharply since the mid-1990s. 1, 2 The majority of thyroid …

Abstract Background BRAF V600E and TERT promoter alterations are core components in
current genetics-based risk assessment for precision management of papillary thyroid …

Background Accurate preoperative assessment of thyroid nodules with fine‐needle
aspiration biopsy (FNAB) continues to be a challenge, often resulting in unnecessary …

Importance Thyroid cancer, predominantly papillary thyroid carcinoma (PTC), is common,
but an estimated 30% of ultrasonography-guided fine-needle aspiration (FNA) biopsies of …

Background Fine needle aspiration (FNA) is widely utilized for evaluation of patients with
thyroid nodules. However, approximately 30% are indeterminate for malignancy. Recently, a …

Background Thyroid nodules are usually diagnosed using fine-needle aspiration (FNA). The
sensitivity limitations of FNA result in 10–30% of nodules being classified as “indeterminate” …

Abstract Background The BRAFV600E mutation is valuable for the diagnosis, prognosis,
and therapy of papillary thyroid cancer (PTC). However, studies related to this mutation have …

BRAF molecular testing holds promise as a possible diagnostic tool for indeterminate FNAs,
and as a determinant for planning initial clinical management of thyroid nodules. Further …