Highlights•Plant natural products are a source of established and novel pharmaceuticals.•To
access the full diversity requires understanding of biosynthetic origins.•Co-expression is a …

Highlights•Transcriptomics is accelerating pathway discovery in diverse plant
species.•Genome mining algorithms for plant biosynthetic gene clusters have been …

Major hurdles in plant biosynthetic pathway elucidation and engineering include the need
for rapid testing of enzyme candidates and the lack of complex substrates that are often not …

Highlights•Challenges in pathway discovery of plant natural products (PNPs).•Multiomics-
guided pathway prediction strategies and tools.•Biochemical characterization of putative …

Elucidating plant-specialized biosynthetic pathways has always constituted a laborious task,
notably for natural products with high pharmaceutical values. Here, we discuss emerging …

Covering: up to 2022 With the emergence of large amounts of omics data, computational
approaches for the identification of plant natural product biosynthetic pathways and their …

Medicinal plants are the abundant source of varied secondary metabolites with important
therapeutic properties. These plants and their extracts have been the basis of several …

Plants produce a vast array of chemical compounds that we use as medicines and flavors,
but these compounds' biosynthetic pathways are still poorly understood. This paucity …

Genome-enabled discoveries are the hallmark of 21st century biology, including major
discoveries in the biosynthesis and regulation of plant metabolic pathways. Access to next …

Plants synthesize an extensive array of secondary metabolites, often with highly complex
structures. Currently, most pharmaceutically important secondary metabolites are isolated …