Much research on transcription factor biology and their genetic pathways has been
undertaken over the last 30 years, especially in the field of developmental biology and …

Biophysical parameters that govern transcription factors activity are binding locations across
the genome, dwelling time at these regulatory elements and specific protein-protein …

Transcription factors play an important role in the long-term regulation of cell growth,
differentiation and responses to environmental cues. There is growing evidence that these …

Traditionally, drug discovery has relied on the systematic screening of natural products and
synthetic chemicals in biological and pharmacological assays that utilize whole animals or …

Aberrant gene expression is a fundamental cause of many disease-associated
pathophysiologies. The pharmacological modulation of transcription factor activity therefore …

Misregulated transcription factors play prominent roles in human disease, but their dynamic
protein-protein interaction network has long made the goal of transcription-targeted …

Many human diseases are characterized by altered gene expression patterns caused by
malfunctioning transcriptional regulators. This has spurred new efforts in the development of …

Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …

Given the correlation between many human diseases and mis-regulated transcription, there
is a growing need for molecules that can inhibit or mimic key interactions between …