Prostate cancer is the most common cancer among men in the United States, and aberrant
DNA methylation is known to be an early molecular event in its development. Here, we have …

Retinoids, which include vitamin A (retinol) and metabolites such as retinoic acid, can inhibit
tumor growth and reverse carcinogenesis in animal models of prostate cancer. We analyzed …

Previous gene array data from our laboratory identified the retinoic acid (RA) biosynthesis
enzyme aldehyde dehydrogenase 1A3 (ALDH1A3) as a putative androgen-responsive gene …

Aldehyde dehydrogenase 1 family member A2 (ALDH1A2) is a rate-limiting enzyme
involved in cellular retinoic acid synthesis. However, its functional role in ovarian cancer …

Aldehyde dehydrogenase (ALDH) 1A enzymes produce retinoic acid (RA), a transcription
induction molecule. To investigate if ALDH1A1 or ALDH1A3-mediated RA signaling has an …

All-trans-retinoic acid (atRA), the oxidized form of vitamin A (retinol), regulates a wide variety
of biological processes, such as cell proliferation and differentiation. Multiple alcohol, retinol …

Rationale: Current therapies for metastatic osseous disease frequently fail to provide a
durable treatment response. To date, there are only limited therapeutic options for metastatic …

Purpose: Histone deacetylase (HDAC) inhibitors have been shown to reverse epigenetic
repression of certain genes, including retinoic acid receptor β2 (RARβ2). In this study, we …

BACKGROUND In retinoid resistant epithelial tumors, the lack of retinoic acid receptor β2
(RARβ2) expression due to epigenetic silencing impairs the activation of retinoid target …

ALDH1A1 metabolizes a variety of endogenous and exogenous aldehyde, and also
oxidizes retinol to synthesize retinoic acid and modulate cell differentiation. Moreover …