[HTML][HTML] Placental galectins regulate innate and adaptive immune responses in pregnancy

O Oravecz, R Romero, E Toth, J Kapitany… - Frontiers in …, 2022 - frontiersin.org
Introduction Galectins are master regulators of maternal immune responses and
placentation in pregnancy. Galectin-13 (gal-13) and galectin-14 (gal-14) are expressed …

[HTML][HTML] Placental galectins are key players in regulating the maternal adaptive immune response

A Balogh, E Toth, R Romero, K Parej, D Csala… - Frontiers in …, 2019 - frontiersin.org
Galectins are potent immunomodulators that regulate maternal immune responses in
pregnancy and prevent the rejection of the semi-allogeneic fetus that also occurs in …

[HTML][HTML] Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)

SM Blois, S Verlohren, G Wu, G Clark, A Dell… - Seminars in …, 2020 - Springer
Growing evidence suggests that galectins, an evolutionarily conserved family of glycan-
binding proteins, fulfill key roles in pregnancy including blastocyst implantation, maternal …

[HTML][HTML] Medawar's PostEra: galectins emerged as key players during fetal-maternal glycoimmune adaptation

E Menkhorst, NG Than, U Jeschke… - Frontiers in …, 2021 - frontiersin.org
Lectin-glycan interactions, in particular those mediated by the galectin family, regulate many
processes required for a successful pregnancy. Over the past decades, increasing evidence …

Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy

I Tirado-Gonzalez, N Freitag… - MHR: Basic science …, 2012 - academic.oup.com
Abstract Galectin-1 (gal-1) is expressed at the feto-maternal interface and plays a role in
regulating the maternal immune response against placental alloantigens, contributing to …

Galectins are critical regulators of cytokine signalling at feto-maternal interface in infection-associated spontaneous preterm birth

T Bhati, A Ray, R Arora, F Siraj, S Parvez, S Rastogi - Placenta, 2023 - Elsevier
Introduction Spontaneous preterm birth (sPTB) is a global health issue. Studies suggest
infections are chiefly associated with sPTB and galectins (gals) play a role in regulation of …

[HTML][HTML] Pregnancy galectinology: insights into a complex network of glycan binding proteins

SM Blois, G Dveksler, GR Vasta, N Freitag… - Frontiers in …, 2019 - frontiersin.org
Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins,
consisting of 15 different types, each with a specific function. Galectins contribute to …

[HTML][HTML] Placental protein 13 (PP13)–a placental immunoregulatory galectin protecting pregnancy

NG Than, A Balogh, R Romero, É Kárpáti… - Frontiers in …, 2014 - frontiersin.org
Galectins are glycan-binding proteins that regulate innate and adaptive immune responses,
and some confer maternal-fetal immune tolerance in eutherian mammals. A chromosome 19 …

[HTML][HTML] Galectin-levels are elevated in infants born preterm due to amniotic infection and rapidly decline in the neonatal period

K Faust, N Freitag, G Barrientos, C Hartel… - Frontiers in …, 2021 - frontiersin.org
Galectin (gal)-1,-3, and-9 are members of a family of glycan binding proteins that mediate
complex interactions between decidual, inflammatory and trophoblast cells modulating …

'Sweetening'pregnancy: galectins at the fetomaternal interface

AG Blidner, GA Rabinovich - American Journal of Reproductive …, 2013 - Wiley Online Library
Successful mammalian pregnancy relies upon acceptance of a semi‐allogeneic fetus by the
maternal immune system. Lessons learned from studies on protective immunity to microbial …