Rough‐Form Lipopolysaccharide Increases Apoptosis in Human CD4+ and CD8+ T Lymphocytes

JS Nielsen, A Larsson, T Ledet, M Turina… - Scandinavian …, 2012 - Wiley Online Library
Immunosuppression induced by lymphocyte apoptosis is considered an important factor in
the pathogenesis of sepsis and has been demonstrated in both animal models of …

Administration to mouse of endotoxin from gram‐negative bacteria leads to activation and apoptosis of T lymphocytes

A Castro, V Bemer, A Nobrega… - European journal of …, 1998 - Wiley Online Library
Lipopolysaccharide (LPS) from gramnegative bacteria is a well‐known T cell‐independent B
lymphocyte mitogen and macrophage/monocyte activator. While the conventional view …

Apoptotic cells protect mice against lipopolysaccharide-induced shock

Y Ren, Y Xie, G Jiang, J Fan, J Yeung, W Li… - The Journal of …, 2008 - journals.aai.org
LPS is a main causative agent of septic shock. There is a lack of effective therapies. In vitro
studies have shown that uptake of apoptotic cells actively inhibits the secretion by activated …

In-vivo induction of apoptosis in murine lymphocytes by bacterial lipopolysaccharides

M Norimatsu, T Ono, A Aoki… - Journal of medical …, 1995 - microbiologyresearch.org
The effect of bacterial lipopolysaccharide (LPS) on the lymphoid organs in C3H/HeN and
C3H/HeJ mice was investigated. In C3H/HeN mice, LPS induced apoptosis, characterised …

A human whole blood model of LPS-mediated suppression of T cell activation.

S Yaqub, V Solhaug, T Vang, R Solberg… - … Medical Journal of …, 2003 - europepmc.org
Background Lipopolysaccharide (LPS) is the main initiator of the early signaling events
leading to sepsis caused by Gram-negative bacteria. Late stages of sepsis are associated …

Lipopolysaccharide inhibits TNF-induced apoptosis: role of nuclear factor-κB activation and reactive oxygen intermediates

SK Manna, BB Aggarwal - The Journal of Immunology, 1999 - journals.aai.org
LPS, a component of the cell wall in Gram-negative bacteria, induces inflammation and
septic shock syndrome by stimulating various inflammatory cytokines including TNF. How …

Lipopolysaccharide—cell interaction and induced cellular activation in whole blood of septic patients

R Salomao, MKC Brunialti, EG Kallás… - Journal of …, 2002 - journals.sagepub.com
We used biotinylatedLPS (LPSb) and flow cytometry to study LPS—monocyte interaction
and LPS-induced cellular activation in whole blood from septic patients (SP). Expression of …

Lipopolysaccharide stimulates butyric acid-induced apoptosis in human peripheral blood mononuclear cells

T Kurita-Ochiai, K Fukushima, K Ochiai - Infection and immunity, 1999 - Am Soc Microbiol
We previously reported that butyric acid, an extracellular metabolite from periodontopathic
bacteria, induced apoptosis in murine thymocytes, splenic T cells, and human Jurkat T cells …

Protection against lipopolysaccharide-induced immunosuppression by IgG and IgM

C Kyvelidou, D Sotiriou, I Zerva, I Athanassakis - Shock, 2018 - journals.lww.com
Lipopolysaccharide (LPS) is commonly used in murine sepsis models, which are largely
associated with immunosuppression and collapse of the immune system. After adapting the …

Role of tumor necrosis factor-α and glucocorticoid on lipopolysaccharide (LPS)-induced apoptosis of thymocytes

Y Kato, A Morikawa, T Sugiyama… - FEMS Immunology & …, 1995 - academic.oup.com
Administration of bacterial lipopolysaccharide (LPS) into mice markedly induced the
apoptosis of CD4+ 8+ thymocytes. The injection of anti-tumor necrosis factor (TNF)-α …