Homomeric and heteromeric α7 nicotinic acetylcholine receptors in health and some central nervous system diseases

V Borroni, FJ Barrantes - Membranes, 2021 - mdpi.com
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels
involved in the modulation of essential brain functions such as memory, learning, and …

Understanding the bases of function and modulation of α7 nicotinic receptors: implications for drug discovery

J Corradi, C Bouzat - Molecular pharmacology, 2016 - ASPET
The nicotinic acetylcholine receptor (nAChR) belongs to a superfamily of pentameric ligand-
gated ion channels involved in many physiologic and pathologic processes. Among …

Therapeutic potential of α7 nicotinic acetylcholine receptors

D Bertrand, CHL Lee, D Flood, F Marger… - Pharmacological …, 2015 - ASPET
Progress in the fields of neuroscience and molecular biology has identified the forebrain
cholinergic system as being important in many higher order brain functions. Further analysis …

Molecular function of α7 nicotinic receptors as drug targets

C Bouzat, M Lasala, BE Nielsen… - The Journal of …, 2018 - Wiley Online Library
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand‐gated ion channels
involved in many physiological and pathological processes. In vertebrates, there are …

Heteromeric α7β2 nicotinic acetylcholine receptors in the brain

J Wu, Q Liu, P Tang, JD Mikkelsen, J Shen… - Trends in …, 2016 - cell.com
The α7 nicotinic acetylcholine receptor (α7 nAChR) is highly expressed in the brain, where it
maintains various neuronal functions including (but not limited to) learning and memory. In …

α7 nicotinic acetylcholine receptors: a therapeutic target in the structure era

A Taly, S Charon - Current Drug Targets, 2012 - ingentaconnect.com
The nicotinic acetylcholine receptors (nAChR) are ligand-gated ion channels involved in
cognitive processes and are associated with brain disorders which makes them interesting …

Alpha7 neuronal nicotinic receptor: a pluripotent target for diseases of the central nervous system

M Bencherif, ST Narla… - CNS & Neurological …, 2014 - ingentaconnect.com
Twenty years ago the alpha7 nicotinic acetylcholine receptor (nAChR) was thought to be
vestigial with little biological relevance, but in recent years it has emerged as a functional …

Detection of α7 nicotinic acetylcholine receptors with the aid of antibodies and toxins

V Tsetlin, I Shelukhina, E Kryukova, G Burbaeva… - Life sciences, 2007 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChRs) containing α7 subunit are well
represented in the brain and some non-neuronal tissues, and their malfunctioning is …

Two neuronal nicotinic acetylcholine receptors, α4β4 and α7, show differential agonist binding modes

NL Puskar, X Xiu, HA Lester, DA Dougherty - Journal of Biological …, 2011 - ASBMB
Nicotinic acetylcholine receptors (nAChRs) are pentameric, neurotransmitter-gated ion
channels responsible for rapid excitatory neurotransmission in the central and peripheral …

[HTML][HTML] Cellular responses and functions of α7 nicotinic acetylcholine receptor activation in the brain: A narrative review

ZQ Xu, WJ Zhang, DF Su, GQ Zhang… - Annals of translational …, 2021 - ncbi.nlm.nih.gov
The α7 nicotinic acetylcholine receptor (α7nAChR) has been studied for many years since
its discovery. Although many functions and characteristics of brain α7nAChR are widely …