The development of thrombotic disorders in humans is one of the most common causes of
morbidity and mortality in the Western world. Thrombotic disease can be classified in broad …

Venous thrombosis is a multifactorial disease. Multiple interactions between genetic and
environmental factors contribute to the development of the disease. Presently, we know of …

Venous thrombosis, whose main clinical presentations include deep vein thrombosis and
pulmonary embolism, represents a major health problem worldwide. Numerous conditions …

A diagnosis of venous thrombosis is made each year in about 0.1% of Western populations.
In the majority of cases, the diagnosis is based on objective evidence for an obstruction of …

Genetic studies in thrombosis started with coining of the term thrombophilia by Jordan and
Nandorff in 1956. Next, antithrombin deficiency was identified in 1965 as a simple genetic …

Background—Recent studies have described genetic mutations that affect the risk of
thrombosis as a result of abnormal levels of such hemostatic parameters as protein C …

Levels of fibrinogen, factor VII (FVII), factor XIII (FXIII), plasminogen activator inhibitor (PAI)-1,
and tissue plasminogen activator have been associated with coronary artery disease as …

Venous thrombosis (deep vein thrombosis, pulmonary embolism) is a common and serious
disorder, with genetic and acquired risk factors. The genetic risk factors can be subdivided in …

Although there are a number of well-characterized genetic defects that lead to increased risk
of thrombosis, little information is available on the relative importance of genetic factors in …

The annual incidence of venous thrombosis, one of the leading causes of mortality and
morbidity, increases from 1 per 100,000 during childhood to 1 per 100 in old age. 1 In this …