Abstract Purpose of Review Pain in rheumatoid arthritis (RA) may be due to different
etiologies, ranging from peripheral inflammation to dysregulation of central nervous system …

Pain is the most common symptom in patients with rheumatoid arthritis (RA). Although in
recent years, through the implementation of targeted treatment and the introduction of …

Understanding of the causes and underlying mechanisms of pain in people with RA is
rapidly changing. With the advent of more effective disease modifying drugs, joint …

There are over 100 different types of arthritis and each can differ greatly in their aetiology
and pathophysiology; however, one characteristic that is common to all arthritic conditions is …

People with rheumatoid arthritis (RA) identify pain as their most important symptom, one that
often persists despite optimal control of inflammatory disease. RA pain arises from multiple …

Pain is a prominent component of many rheumatologic conditions, and is the result of a
complex physiologic interaction of central and peripheral nervous system signaling that …

Although pain in rheumatoid arthritis (RA) is frequently thought to be inflammatory in nature,
the association between measures of inflammation and pain intensity is low. This …

Objectives Osteoarthritis (OA) is the leading cause of musculoskeletal pain and functional
disability worldwide, affecting a growing number of individuals in the western society …

The mechanisms underlying chronic pain states, including osteoarthritis, differ from those
underlying acute pain. In chronic pain states, central nervous system (CNS) factors often …

Pain is a major clinical problem of osteoarthritis (OA). Recently, OA has been thought to be a
disease of the whole joint with both destruction of cartilage and inflammatory components …