Objectives: 1) To determine the incidence and severity of hyperkalemia during trimethoprim
therapy. 2) To test the hypothesis that trimethoprim inhibits renal potassium excretion by …

Objective: To determine the effect of standard-dose trimethoprim-sulfamethoxazole on
serum potassium concentration in hospitalized patients. Design: Prospective chart review …

Objective: To determine the effect of trimethoprim-sulfamethoxazole (Tmp-Smx) on serum
potassium concentration. Design: Retrospective cohort study. Setting: An urban teaching …

Trimethoprim-sulfamethoxazole is a frequently prescribed antibiotic with a wide spectrum of
antimicrobial activity. As a result of the increasing number of AIDS patients requiring therapy …

Cotrimoxazole (trimethoprim-sulfamethoxazole) is a combination antimicrobial that is
frequently used to treat a wide variety of infections. Only recently has hyperkalaemia been …

Trimethoprim-sulfamethoxazole therapy was studied in persons with normal and impaired
renal function, who were given a single oral dose of the combined drug. Oral acid loading …

K+ sparing diuretic actions of trimethoprim: Inhibition of Na+ channels in A6 distal nephron
cells. Hyperkalemia complicates trimethoprim-sulfamethoxazole (TMP-SMX) therapy in over …

The effect of trimethuprim (TMP) on serum creatinine concentration (SCr) was studied in 10
healthy (H) subjects and nine subjects with chronic renal failure (CRF). Each volunteer was …

Objective High-dose trimethoprim-sulfamethoxazole (TMP-SMX) is known to cause
hyperkalemia by blocking amiloride-sensitive sodium (Na) channels in distal nephrons. The …

The effects of a 10-day course of moderate-dose (10 mg/kg/day) or high-dose (20
mg/kg/day) trimethoprim therapy on serum creatinine, measured creatinine clearance …