Over the past few decades, extensive research has shed light on immune alterations and the
significance of dysfunctional biological barriers in psychiatric disorders. The leaky gut …

Abstract Sphingosine-1-phosphate (S1P) and S1P receptors (S1PR) are ubiquitously
expressed. S1P-S1PR signaling has been well characterized in immune trafficking and …

The physiological functions of sphingosine 1-phosphate (S1P) and its pathological roles in
various diseases are increasingly being elucidated. Particularly, a growing body of literature …

Inflammation is an important immune response of the body. It is a physiological process of
self-repair and defense against pathogens taken up by biological tissues when stimulated …

Sphingosine 1-phosphate (S1P), derived from membrane sphingolipids, is a pleiotropic
bioactive lipid mediator capable of evoking complex immune phenomena. Studies have …

Sphingolipids are essential components of all eukaryotic membranes. The bioactive
sphingolipid molecule, Sphingosine 1-Phosphate (S1P), regulates various important …

Sphingosine 1-phosphate (S1P) is a signaling molecule with complex biological functions
that are exerted through the activation of sphingosine 1-phosphate receptors 1–5 (S1PR1 …

Abstract Sphingosine-1 phosphate (S1P), a bioactive sphingolipid metabolite, plays an
essential role in cellular homeostasis. It is well evidenced that enzymes responsible for S1P …

Abstract Sphingosine-1-phosphate (S1P) is a versatile sphingolipid that is generated
through the phosphorylation of sphingosine by sphingosine kinase (SPHK). S1P exerts its …

Sphingosine-1-phosphate (S1P), a type of bioactive sphingolipid, can regulate various
cellular functions of distinct cell types in the human body. S1P is generated intracellularly by …