Decipher: A computational pipeline to extract context-specific mechanistic insights from single-cell profiles
EA Basto Piamonte, B Wajid, J Read, J Armitage… - bioRxiv, 2024 - biorxiv.org
The advent of single-cell profiling technologies has revolutionized our understanding of the
cellular and molecular states that underpin disease states and response to therapies …
cellular and molecular states that underpin disease states and response to therapies …
Decipher: A computational pipeline to extract context-specific mechanistic insights from single-cell profiles
E Basto, B Wajid, J Read, J Armitage, J Waithman… - 2024 - europepmc.org
The advent of single-cell profiling technologies has revolutionized our understanding of the
cellular and molecular states that underpin disease states and response to therapies …
cellular and molecular states that underpin disease states and response to therapies …
Multi-resolution single-cell state characterization via joint archetypal/network analysis
Dissecting the cellular heterogeneity embedded in single-cell transcriptomic data is
challenging. Although a large number of methods and approaches exist, robustly identifying …
challenging. Although a large number of methods and approaches exist, robustly identifying …
[HTML][HTML] Implicating gene and cell networks responsible for differential COVID-19 host responses via an interactive single cell web portal
K Jin, EE Bardes, A Mitelpunkt, JY Wang, S Bhatnagar… - bioRxiv, 2021 - ncbi.nlm.nih.gov
Numerous studies have provided single-cell transcriptome profiles of host responses to
SARS-CoV-2 infection. Critically lacking however is a datamine that allows users to compare …
SARS-CoV-2 infection. Critically lacking however is a datamine that allows users to compare …
Identification of COVID-19-relevant transcriptional regulatory networks and associated kinases as potential therapeutic targets
Identification of transcriptional regulatory mechanisms and signaling networks involved in
the response of host to infection by SARS-CoV-2 is a powerful approach that provides a …
the response of host to infection by SARS-CoV-2 is a powerful approach that provides a …
[HTML][HTML] Profiling transcription initiation in peripheral leukocytes reveals severity-associated cis-regulatory elements in critical COVID-19
The contribution of transcription factors (TFs) and gene regulatory programs in the immune
response to COVID-19 and their relationship to disease outcome is not fully understood …
response to COVID-19 and their relationship to disease outcome is not fully understood …
Meta-analysis of virus-induced host gene expression reveals unique signatures of immune dysregulation induced by SARS-CoV-2
The clinical outcome of COVID-19 has an extreme age, genetic and comorbidity bias that is
thought to be driven by an impaired immune response to SARS-CoV-2, the causative agent …
thought to be driven by an impaired immune response to SARS-CoV-2, the causative agent …
Systematic reconstruction of molecular pathway signatures using scalable single-cell perturbation screens
L Jiang, C Dalgarno, E Papalexi, I Mascio, HH Wessels… - bioRxiv, 2024 - biorxiv.org
Recent advancements in functional genomics have provided an unprecedented ability to
measure diverse molecular modalities, but learning causal regulatory relationships from …
measure diverse molecular modalities, but learning causal regulatory relationships from …
[图书][B] The Host Response to SARS-CoV-2 and Testing of Therapeutics against COVID-19
R Møller - 2021 - search.proquest.com
The emergence of SARS-CoV-2 and the pandemic of COVID-19 that followed have caused
societal disruption and a significant loss of human lives. The pathology of COVID-19 is …
societal disruption and a significant loss of human lives. The pathology of COVID-19 is …
A multiresolution framework to characterize single-cell state landscapes
Dissecting the cellular heterogeneity embedded in single-cell transcriptomic data is
challenging. Although a large number of methods and approaches exist, robustly identifying …
challenging. Although a large number of methods and approaches exist, robustly identifying …