Toxicity induced by ciprofloxacin and enrofloxacin: oxidative stress and metabolism

S Badawy, YQ Yang, Y Liu, MA Marawan… - Critical Reviews in …, 2021 - Taylor & Francis
Abstract Ciprofloxacin (CIP)(human use) and enrofloxacin (ENR)(veterinary use) are
synthetic anti-infectious medications that belong to the second generation of …

[PDF][PDF] Ciprofloxacin increases hepatic and renal lipid hydroperoxides levels in mice

AI Weyers, LI Ugnia, HG Ovando, NB Gorla - Biocell, 2002 - pdfs.semanticscholar.org
Ciprofloxacin (CFX) is an effective and relatively safe antimicrobial used in a variety of
human infections. However, adverse drug reactions and positive results in genotoxic tests …

A proposed “steric-like effect” for the slowdown of enrofloxacin antibiotic metabolism by ciprofloxacin, and its mechanism

X Xu, Q Lu, Y Yang, MA Martínez, B Lopez-Torres… - Chemosphere, 2021 - Elsevier
The results of monitoring over the years have shown that the mixing and coexistence of
various low-level antibiotic residual pollutants has increased significantly, among which, the …

Microsomal metabolism of ciprofloxacin generates free radicals

A Gürbay, B Gonthier, D Daveloose, A Favier… - Free Radical Biology …, 2001 - Elsevier
Ciprofloxacin (CPFX) is a widely used fluoroquinolone antibiotic with a broad spectrum of
activity. However, clinical experience has shown a possible incidence of undesirable …

Ciprofloxacin cardiotoxicity and hepatotoxicity in humans and animals

E Adikwu, N Brambaifa - Pharmacology & Pharmacy, 2012 - eprints.go4mailburst.com
Ciprofloxacin is generally well tolerated; the most common adverse effects include gastro
intestinal tract, central nervous system and hematological system effects. Recently rising …

Oxidative stress induced by fluoroquinolone enrofloxacin in zebrafish (Danio rerio) can be ameliorated after a prolonged exposure

P Sehonova, N Tokanova, N Hodkovicova… - Environmental …, 2019 - Elsevier
The purpose of our experiment was to evaluate the effect of enrofloxacin on
biotransformation, oxidative stress and mRNA expression of related genes in fish as a non …

Responses of Cirrhinus mrigala to second‐generation fluoroquinolone (ciprofloxacin) toxicity: Assessment of antioxidants, tissue morphology, and inorganic ions

M Ramesh, M Sujitha, PA Anila, Z Ren… - Environmental …, 2021 - Wiley Online Library
Ciprofloxacin drugs are a second‐generation fluoroquinolone highly prescribed medication
against various bacterial infections in human and aquaculture practices. These drugs are …

Ciprofloxacin-induced antibacterial activity is reversed by vitamin E and vitamin C

MM Masadeh, NM Mhaidat, KH Alzoubi… - Current …, 2012 - Springer
In the present study, we investigated the possible involvement of oxidative stress in
ciprofloxacin-induced cytotoxicity against several reference bacteria including …

[HTML][HTML] Ciprofloxacin-induced antibacterial activity is atteneuated by pretreatment with antioxidant agents

MM Masadeh, KH Alzoubi, SI Al-Azzam, OF Khabour… - Pathogens, 2016 - mdpi.com
Ciprofloxacin works through interfering with replication and transcription of bacterial DNA,
which leads to increased oxidative stress, and death of bacterial cells. Drugs with strong …

Long-term toxicity of fluoroquinolones: a comprehensive review

NHA Hussen, SH Qadir, HS Rahman… - Drug and Chemical …, 2023 - Taylor & Francis
Fluoroquinolones (FQs) are highly potent bactericidal antibiotics with broad-spectrum
activity against Gram-negative/positive bacteria. The Food and Drug Administration (FDA) …