The role of ceramide synthases in the pathogenicity of Cryptococcus neoformans
Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases
every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans …
every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans …
Lipid metabolism in Cryptococcus neoformans
JM Shea, JL Henry, M Del Poeta - FEMS yeast research, 2006 - academic.oup.com
In recent years, lipids have been shown to act as signalling molecules not only in
mammalian cells but also in many other eukaryotes. Whereas in mammalian cells lipids …
mammalian cells but also in many other eukaryotes. Whereas in mammalian cells lipids …
Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans
C Luberto, DL Toffaletti, EA Wills… - Genes & …, 2001 - genesdev.cshlp.org
Cryptococcus neoformans is a leading cause of life-threatening fungal infection in
immunocompromised patients. Inositol-phosphoryl ceramide synthase 1 (Ipc1) is a fungus …
immunocompromised patients. Inositol-phosphoryl ceramide synthase 1 (Ipc1) is a fungus …
Hydroxyurea treatment inhibits proliferation of Cryptococcus neoformans in mice
K Tripathi, V Mor, NK Bairwa, M Del Poeta… - Frontiers in …, 2012 - frontiersin.org
The fungal pathogen Cryptococcus neoformans (Cn) is a serious threat to
immunocompromised individuals, especially for HIV patients who develop …
immunocompromised individuals, especially for HIV patients who develop …
Lipid flippase subunit Cdc50 mediates drug resistance and virulence in Cryptococcus neoformans
Cryptococcus neoformans is a human fungal pathogen and a major cause of fungal
meningitis in immunocompromised individuals. Treatment options for cryptococcosis are …
meningitis in immunocompromised individuals. Treatment options for cryptococcosis are …
Surface Localization of Glucosylceramide during Cryptococcus neoformans Infection Allows Targeting as a Potential Antifungal
R Rhome, A Singh, T Kechichian, M Drago, G Morace… - PLoS …, 2011 - journals.plos.org
Cryptococcus neoformans (Cn) is a significant human pathogen that, despite current
treatments, continues to have a high morbidity rate especially in sub-Saharan Africa. The …
treatments, continues to have a high morbidity rate especially in sub-Saharan Africa. The …
Biosynthesis and Immunogenicity of Glucosylceramide in Cryptococcus neoformans and Other Human Pathogens
R Rhome, T McQuiston, T Kechichian… - Eukaryotic …, 2007 - Am Soc Microbiol
Cryptococcus neoformans var. grubii (serotype A) and Cryptococcus neoformans var.
neoformans (serotype D), and C. gattii comprises serotypes B and C (47). Infection occurs …
neoformans (serotype D), and C. gattii comprises serotypes B and C (47). Infection occurs …
A single protein S-acyl transferase acts through diverse substrates to determine cryptococcal morphology, stress tolerance, and pathogenic outcome
Cryptococcus neoformans is an opportunistic yeast that kills over 625,000 people yearly
through lethal meningitis. Host phagocytes serve as the first line of defense against this …
through lethal meningitis. Host phagocytes serve as the first line of defense against this …
Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans
In previous studies we showed that the replication of Cryptococcus neoformans in the lung
environment is controlled by the glucosylceramide (GlcCer) synthase gene (GCS1), which …
environment is controlled by the glucosylceramide (GlcCer) synthase gene (GCS1), which …
All about that fat: Lipid modification of proteins in Cryptococcus neoformans
FH Santiago-Tirado, TL Doering - Journal of microbiology, 2016 - Springer
Lipid modification of proteins is a widespread, essential process whereby fatty acids,
cholesterol, isoprenoids, phospholipids, or glycosylphospholipids are attached to …
cholesterol, isoprenoids, phospholipids, or glycosylphospholipids are attached to …