Atopic dermatitis (AD) is a multifaceted, chronic relapsing inflammatory skin disease that
affects people of all ages. It is characterized by chronic eczema, constant pruritus, and …

Transient receptor potential (TRP) ion channels were first characterized on neurons, where
they are classically implicated in sensory functions; however, research in recent decades …

Background Chronic itch is a highly debilitating symptom that underlies many medical
disorders with no universally effective treatments. Although unique neuronal signaling …

Itch in atopic dermatitis (AD) is aggravated under warm conditions. Transient receptor
potential vanilloid (TRPV) 3, a member of the thermosensitive transient receptor potential …

Chronic debilitating pruritus is a cardinal feature of atopic dermatitis (AD). Little is known
about the underlying mechanisms. Antihistamines lack efficacy in treating itch in AD …

BACKGROUND: Transient receptor potential vanilloid type 1 (TRPV1) is a cation channel
activated by diverse obnoxious stimuli like capsaicin, low pH or heat. Recently, it was …

TRPV1 is a non-selective channel receptor widely expressed in skin tissues, including
keratinocytes, peripheral sensory nerve fibers and immune cells. It is activated by a variety of …

Allergic contact dermatitis is a common skin disease associated with inflammation and
persistent pruritus. Transient receptor potential (TRP) ion channels in skin-innervating …

abstract Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely
pruritic skin disorder mostly associated with IgE elevation and skin barrier dysfunction due to …

Emerging evidence suggests that transient receptor potential (TRP) ion channels not only
act as 'polymodal cellular sensors' on sensory neurons but are also functionally expressed …