The authors have conducted a systematic analysis of the data available in modern literature
on the role of genetic testing for mutations in the genes responsible for a predisposition to …

During the last 5 years progress in molecular genetics has offered the possibility of genetic
testing for inherited mutations of cancer-predisposing genes. The exact cellular function and …

A variety of hereditary cancer syndromes contribute to the development of gynecological
cancers. These syndromes are caused due to germline pathogenic variants (GPVs) in tumor …

Abstract A proportion—often 10 to 20%—of all cancers are caused by a congenital gene
mutation. The genetic results play a crucial role in the planning of surveillance for the patient …

Genetic testing for a hereditary predisposition to gynecologic cancers has been available
clinically since the 1990s. Since then, knowledge of the hereditary contribution to …

Up to 10% of some types of gynecological cancer can be attributed to a genetic
predisposition. Women at high-risk of these cancers because of their family history or a …

Approximately 10% of cancer deaths in women in Westernised countries are due to
gynaecological malignancy. Cancer results from the accumulation of multiple genetic …

In recent years, the genetic aspects of cancer have become important for everyday practice
in many fields of medicine. Recognition of the hereditary nature ofcommon'cancers in certain …

To determine the validity of observations suggesting a significant dichotomy of gynecologic
cancers determined by linkage to specific genetic defects associated with two major …

Genes and cancer: Genetic counselling and clinical management — Research Profiles at
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