Animal models are pivotal for understanding the mechanism of neuropathic pain and
development of effective therapy for its optimal management. A battery of neuropathic pain …

Chronic pain is a global problem that has reached epidemic proportions. An estimated 20%
of adults suffer from pain, and another 10% are diagnosed with chronic pain each year …

Neuropathic pain remains an area of considerable unmet clinical need. Research based on
preclinical animal models has failed to deliver truly novel treatment options, questioning the …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

Neuropathic pain encompasses a broad range of conditions associated with a lesion or
disease of the peripheral or central somatosensory system and its prevalence in the general …

One of the biggest challenges for discovering more efficacious drugs for the control of
neuropathic pain has been the diversity of chronic pain states in humans. It is now …

Neuropathic Pain (NP) is a painful condition which is a direct consequence of a lesion or
disease affecting the somatosensory system with symptoms like allodynia, hyperalgesia. It …

The paper addresses issues related to the clinical relevance of currently employed animal
models of neuropathic pain and our inability to translate clinical symptoms and signs into …

Human experimental pain models are essential in understanding the pain mechanisms and
appear to be ideally suited to test analgesic compounds. The challenge that confronts both …

Neuropathic pain refers to pain that originates from pathology of the nervous system.
Diabetes, infection (herpes zoster), nerve compression, nerve trauma, and autoimmune …