During chronic hepatitis B virus (HBV) infection, hepatic fibrosis is a serious pathological
condition caused by virus-induced liver damage. The activation of hepatic stellate cells …

The activation of hepatic stellate cells (HSCs) is closely associated with liver fibrosis in
chronic hepatitis B virus (HBV) infection. However, the molecular mechanisms leading to …

Activation of hepatic stellate cells (HSCs) by transforming growth factor-β1 (TGF-β1) initiates
HBV-associated fibrogenesis. The mechanism of TGF-β1 modulating HSC activation is not …

Liver fibrosis is a manifestation of chronic liver injury. It leads to hepatic dysfunction and is a
critical element in the pathogenesis of cirrhosis and hepatocellular carcinoma. The …

Chronic hepatitis B virus infection is a major cause of hepatic fibrosis, leading to liver
cirrhosis and hepatocellular carcinoma. Hepatitis B virus e antigen (HBeAg) is an accessory …

Background Hepatitis B is at particularly high risk of fibrosis progression. Unfortunately, the
mechanism of hepatic fibrogenesis induced by hepatitis B virus (HBV) has not been fully …

Mechanisms of hepatic fibrogenesis induced by hepatitis C virus (HCV), one of the leading
causes of liver fibrosis, are not fully understood. We studied transcriptional up‐regulation of …

Liver fibrosis is a primary response to injury of etiologies including metabolic abnormalities,
viral (hepatitis C and B virus [HCV/HBV]) and other infections, toxins and drugs. Chronic …

Liver fibrosis is a reversible wound-healing process aimed at maintaining organ integrity,
and presents as the critical pre-stage of liver cirrhosis, which will eventually progress to …

Background Fibrosis results from inflammation and healing following injury. The imbalance
between extracellular matrix (ECM) secretion and degradation leads to the ECM …