The coordination of immunity across organs is fundamental to cancer development and
progression. It is well known that the hostile metabolic microenvironment in the tumour is a …

Cancer cells characteristically consume glucose through Warburg metabolism, a process
that forms the basis of tumour imaging by positron emission tomography (PET). Tumour …

T cell metabolism has a central role in supporting and shaping immune responses and may
have a key role in antitumor immunity. T cell metabolism is normally held under tight …

Neutrophils are critical innate immune cells for the host anti-bacterial defense. Throughout
their lifecycle, neutrophils are exposed to different microenvironments and modulate their …

Neutrophils are a vital component of immune protection, yet in cancer they may promote
tumour progression, partly by generating reactive oxygen species (ROS) that disrupts …

The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating
immune cells and impedes durable clinical remission following immunotherapy. Metabolic …

Tumor microenvironment is characterized by a consistent reduction in oxygen and blood-
borne nutrients that significantly affects the metabolism of distinct cell subsets. Immune cells …

Recent advances in immunotherapies such as immune checkpoint blockade (ICB) and
chimeric antigen receptor T cells (CAR-T) for the treatment of cancer have generated …

Regulatory T (Treg) cells, although vital for immune homeostasis, also represent a major
barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the …

The metabolic characteristics of tumors present considerable hurdles to immune cell
function and cancer immunotherapy. Using a glutamine antagonist, we metabolically …