[HTML][HTML] Medical countermeasures against ricin intoxication

C Rasetti-Escargueil, A Avril - Toxins, 2023 - mdpi.com
Ricin toxin is a disulfide-linked glycoprotein (AB toxin) comprising one enzymatic A chain
(RTA) and one cell-binding B chain (RTB) contained in the castor bean, a Ricinus species …

[HTML][HTML] Isolation of anti-ricin protective antibodies exhibiting high affinity from immunized non-human primates

T Noy-Porat, R Rosenfeld, N Ariel, E Epstein, R Alcalay… - Toxins, 2016 - mdpi.com
Ricin, derived from the castor bean plant Ricinus communis, is one of the most potent and
lethal toxins known, against which there is no available antidote. To date, the use of …

Ricin toxin and its neutralizing antibodies: A review

H Yu, S Li, N Xu, W Liu - Toxicon, 2022 - Elsevier
Ricin toxin (RT) belongs to the ribosome-inactivating protein (RIP) family of toxins and is
considered to be a moderate threat by the US Center of Disease Control and Prevention …

[HTML][HTML] Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity

T Pelat, M Hust, M Hale, MP Lefranc, S Dübel… - BMC …, 2009 - Springer
Background Ricin is a lethal toxin that inhibits protein synthesis. It is easily extracted from a
ubiquitously grown plant, Ricinus communis, and thus readily available for use as a …

[HTML][HTML] Passive and active vaccination strategies to prevent ricin poisoning

SH Pincus, JE Smallshaw, K Song, J Berry, ES Vitetta - Toxins, 2011 - mdpi.com
Ricin toxin (RT) is derived from castor beans, produced by the plant Ricinus communis. RT
and its toxic A chain (RTA) have been used therapeutically to arm ligands that target disease …

[HTML][HTML] Production, characterisation and testing of an ovine antitoxin against ricin; efficacy, potency and mechanisms of action

SJC Whitfield, GD Griffiths, DC Jenner, RJ Gwyther… - Toxins, 2017 - mdpi.com
Ricin is a type II ribosome-inactivating toxin that catalytically inactivates ribosomes ultimately
leading to cell death. The toxicity of ricin along with the prevalence of castor beans (its …

[HTML][HTML] Neutralising antibodies against ricin toxin

J Prigent, L Panigai, P Lamourette, D Sauvaire… - PLoS …, 2011 - journals.plos.org
The Centers for Disease Control and Prevention have listed the potential bioweapon ricin as
a Category B Agent. Ricin is a so-called A/B toxin produced by plants and is one of the …

Conformation‐Dependent High‐Affinity Potent Ricin‐Neutralizing Monoclonal Antibodies

WG Hu, J Yin, D Chau, CC Hu, D Lillico… - BioMed research …, 2013 - Wiley Online Library
Ricin is a potential biothreat agent with no approved antidote available for ricin poisoning.
The aim of this study was to develop potent antibody‐based antiricin antidotes. Four strong …

Monoclonal antibody, mAb 4C13, an effective detoxicant antibody against ricin poisoning

N Dong, L Luo, J Wu, P Jia, Q Li, Y Wang, Z Gao… - Vaccine, 2015 - Elsevier
Ricin is a glycoprotein produced in castor seeds and consists of two polypeptide chains
named Ricin Toxin A Chain (RTA) and Ricin Toxin B Chain (RTB), linked via a disulfide …

[HTML][HTML] Ricin Antibodies' Neutralizing Capacity against Different Ricin Isoforms and Cultivars

ML Orsini Delgado, A Avril, J Prigent, J Dano, A Rouaix… - Toxins, 2021 - mdpi.com
Ricin, a highly toxic protein from Ricinus communis, is considered a potential biowarfare
agent. Despite the many data available, no specific treatment has yet been approved. Due to …