Motivation Gene transcription is a random and noisy process. Tremendous efforts in single-
cell studies have been mapping transcription noises to phenotypic variabilities between …

The molecular processes that drive gene transcription are inherently noisy. This noise often
manifests in the form of transcriptional bursts, producing fluctuations in gene activity over …

Noise is pervasive in cellular biology and inevitably affects the dynamics of cellular
processes. Biological systems have developed regulatory mechanisms to ensure …

Noise in gene expression can lead to reversible phenotypic switching. Several experimental
studies have shown that the abundance distributions of proteins in a population of isogenic …

Recent evidence indicates that transcriptional bursts are intrinsically amplified by
messenger RNA cytoplasmic processing to generate large stochastic fluctuations in protein …

Gene-expression bimodality, as a potential mechanism generating phenotypic cell diversity,
can enhance the survival of cells in a fluctuating environment. Previous studies have shown …

Within a population of genetically identical cells there can be significant variation, or noise,
in gene expression. Yet even with this inherent variability, cells function reliably. This review …

Stochastic gene expression has been implicated in a variety of cellular processes, including
cell differentiation and disease. In this issue of Cell, Weinberger et al.(2005) take an …

Background Gene expression in a cell entails random reaction events occurring over
disparate time scales. Thus, molecular noise that often results in phenotypic and population …

Cells must respond sensitively to time-varying inputs in complex signaling environments. To
understand how signaling networks process dynamic inputs into gene expression outputs …