Clinical evidence highlights a relationship between the blood and the bone, but the
underlying mechanism linking these two tissues is not fully elucidated. Here, we used β …

Iron deficiency is a potent stimulator of fibroblast growth factor 23 (FGF23), a hormonal
regulator of phosphate and vitamin D metabolism, that is classically thought to be produced …

Myelodysplastic neoplasms (MDS) are hematopoietic stem cell disorders characterized by
ineffective hematopoiesis and dysplastic cells in the bone marrow (BM)[1]. In addition …

Hematopoietic stem cells (HSCs) are regulated by signals from the bone marrow (BM) niche
that tune hematopoiesis at steady state and in hematologic disorders. To understand HSC …

Fibroblast growth factor-2 (FGF2) has been demonstrated to be a promising osteogenic
factor for treating osteoporosis. Our earlier study shows that transplantation of mouse Sca-1+ …

Background Cancer cachexia is a wasting syndrome that is quite common in terminal-stage
cancer patients. Cancer-related anemia is one of the main features of cancer cachexia and …

Myelodysplastic syndromes (MDS) are clonal malignant hematopoietic disorders in the
elderly characterized by ineffective hematopoiesis. This is accompanied by an altered bone …

Stromal cells and osteoblasts play major roles in forming and modulating the bone marrow
(BM) hematopoietic microenvironment. We have reported that FGF2 compromises stromal …

FGF1 and FGF2 support hematopoietic stem and progenitor cells (HSPCs) under stress
conditions. In this study, we show that fibroblast growth factor (FGF7) may be a novel niche …

Haematopoietic stem cells (HSCs) are produced during embryogenesis from the floor of the
dorsal aorta. The localization of HSCs is dependent on the presence of instructive signals on …