Endothelial xanthine oxidoreductase (XOR) together with NAD (P) H oxidase and nitric
oxide (NO) synthase plays a physiologic role in inflammatory signalling, the regulation of NO …

The enzyme xanthine oxidoreductase (XOR) catalyses the last step of purine degradation in
the highest uricotelic primates as a rate-limiting enzyme in nucleic acid catabolism. Although …

There is substantial evidence that oxidative stress participates in the pathophysiology of
cardiovascular disease. Biochemical, molecular and pharmacological studies further …

Human xanthine oxidoreductase (XOR) is a multiple-level regulated enzyme, resulting from
a complicated evolutionary process that assigned it many physiological roles. The main …

Xanthine oxidoreductase (XOR) is a ubiquitous metalloflavoprotein that appears in two
interconvertible yet functionally distinct forms: xanthine dehydrogenase (XD), which is …

A plethora of vascular pathology is associated with inflammation, hypoxia and elevated rates
of reactive species generation. A critical source of these reactive species is the purine …

Concentrations of up to 1.5 milliunits/ml xanthine oxidase (XO)(1.1 μg/ml) are found
circulating in plasma during diverse inflammatory events. The saturable, high affinity binding …

Obesity and related pathologies such as diabetes and metabolic syndrome are associated
with chronic inflammation and cancer. The serum level of xanthine oxidoreductase (XOR) is …

In the vascular wall, reactive oxygen species (ROS) are produced by several enzyme
systems including NADPH oxidase, xanthine oxidase, uncoupled endothelial nitric oxide …

Xanthine oxidoreductase (XOR) is the enzyme responsible for the final step in purine
degradation resulting in the generation of uric acid. Here we have generated mice deficient …