Although interferon (IFN) beta is a widely used disease-modifying therapy in multiple
sclerosis (MS), the mechanisms responsible for its effects are not fully understood. Some …

Interferon-β (IFN-β) achieves its beneficial effect on multiple sclerosis (MS) via anti-
inflammatory properties. In this study, we assessed the expression of the brain-derived …

Pathogenic autoimmune cells are demonstrated to be able to produce neurotrophic factors
during acute phase of multiple sclerosis (MS). In this study, we determined the production of …

Background: Within multiple sclerosis lesions, brain-derived neurotrophic factor is detected
in neurons and immunocytes. Objective: To clarify brain-derived neurotrophic factor …

Recent studies have suggested a neuroprotective activity of the lesion-infiltrating immune
cells in multiple sclerosis (MS) by secretion of neurotrophins. We had earlier reported that …

Background: In recent investigations addressing neurodegenerative diseases, especially
multiple sclerosis (MS), the roles of brain-derived neurotrophic factor (BDNF) and interleukin …

Although neurons are the main source of neurotrophins in the healthy brain, neurotrophins
can also be expressed in the immune system. We have previously shown that in relapsing …

Multiple sclerosis (MS), a disease of presumably autoimmune aetiology, is character ized by
inflammation, demyelination and axonal degeneratio n in the central nervous system. C …

Neuronal growth factors may exert a neuroprotective effect in multiple sclerosis (MS). We
found reduced levels of brain-derived neurotrophic factors (BDNF) in the serum and CSF of …

Background Interferon beta therapy has been shown to reduce the rate of clinical relapse
and the frequency of magnetic resonance imaging–defined T2-weighted lesions in patients …