This PhD thesis asked how immune-modulating drugs affect the short term and legacy
response of human CD4+ T cells to different stimuli. It included functional and molecular …

Regulation of the adaptive immune response is critical for health. Regulatory activity can be
found in multiple components of the immune system, however, the focus on particular …

Regulation of immune responses is crucial in order to maintain immunological self-
tolerance. This is maintained in the periphery by a number of cell types that have the …

Human beings are exposed to a variety of different pathogens, which induce tailored
immune responses and consequently generate highly diverse populations of pathogen …

Activation of T lymphocytes during an immune response triggers a series of programmed
gene regulation, proliferation, differentiation, and effector functions. These T-cell functions …

Autoimmune diseases are characterized by dysfunctional immune systems that
misrecognize self as non‐self and cause tissue destruction. Several cell types have been …

The interaction between dendritic cells (DCs) and T cells is crucial on immunity or tolerance
induction. In an immature or semi-mature state, DCs induce tolerance through T-cell …

Regulation of Immune Responses by T Cells | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …

It has been known for over 25 years that CD4 T cell responses are restricted to a finite
number of peptide epitopes within pathogens or protein vaccines. These selected peptide …

Autoimmunity results from defects in immune tolerance pathways that impair the capacity of
immune cells to distinguish between self and non-self. One of these immune tolerance …